5yvk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:25, 27 March 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='5yvk' size='340' side='right'caption='[[5yvk]], [[Resolution|resolution]] 1.29&Aring;' scene=''>
<StructureSection load='5yvk' size='340' side='right'caption='[[5yvk]], [[Resolution|resolution]] 1.29&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5yvk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fischerella_utex1903 Fischerella utex1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YVK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5YVK FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5yvk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fischerella_ambigua_UTEX_1903 Fischerella ambigua UTEX 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YVK FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0HZ:AMINO({3-[(3S,8AS)-1,4-DIOXOOCTAHYDROPYRROLO[1,2-A]PYRAZIN-3-YL]PROPYL}AMINO)METHANIMINIUM'>0HZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.292&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5yvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yvk OCA], [http://pdbe.org/5yvk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yvk RCSB], [http://www.ebi.ac.uk/pdbsum/5yvk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yvk ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0HZ:AMINO({3-[(3S,8AS)-1,4-DIOXOOCTAHYDROPYRROLO[1,2-A]PYRAZIN-3-YL]PROPYL}AMINO)METHANIMINIUM'>0HZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yvk OCA], [https://pdbe.org/5yvk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yvk RCSB], [https://www.ebi.ac.uk/pdbsum/5yvk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yvk ProSAT]</span></td></tr>
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/V5TER4_FISAU V5TER4_FISAU]
-
Found recently in stignomatales, the Stig cyclases catalyze the Cope rearrangement and intramolecular cyclization to produce complex indole alkaloids. Five crystal structures were solved of subfamily 1 and 2 Stig cyclases, which adopt a beta-sandwich fold like the non-catalytic carbohydrate-binding motif. Several complex structures were also determined of indole-based compounds, which are bound to the hydrophobic terminal cavity, where a conserved Asp residue makes an H-bond to the indole N and triggers the acid-catalyzed Cope rearrangement. Through analyzing the enzyme-ligand interactions and mutagenesis experiments, several aromatic residues were found important in catalysis. Apart from a common substrate binding mode and catalytic mechanism, potential subfamily variations that may attribute to the different product specificity are implicated. These results shall expand our scope of enzymology, in particular for further investigation of the biosynthetic Cope rearrangement.
+
-
 
+
-
The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement.,Chen CC, Hu X, Tang X, Yang Y, Ko TP, Gao J, Zheng Y, Huang JW, Yu Z, Li L, Han S, Cai N, Zhang Y, Liu W, Guo RT Angew Chem Int Ed Engl. 2018 Nov 12;57(46):15060-15064. doi:, 10.1002/anie.201808231. Epub 2018 Oct 23. PMID:30222239<ref>PMID:30222239</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 5yvk" style="background-color:#fffaf0;"></div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Fischerella utex1903]]
+
[[Category: Fischerella ambigua UTEX 1903]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Chen, C C]]
+
[[Category: Chen CC]]
-
[[Category: Guo, R T]]
+
[[Category: Guo RT]]
-
[[Category: Hu, X Y]]
+
[[Category: Hu XY]]
-
[[Category: Liu, W D]]
+
[[Category: Liu WD]]
-
[[Category: Prenyltransferase]]
+
-
[[Category: Transferase]]
+

Current revision

Crystal structure of a cyclase Famc1 from Fischerella ambigua UTEX 1903

PDB ID 5yvk

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5yvk"
Personal tools