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RNA uridylyltransferase

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<StructureSection load='' size='350' side='right' caption='RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry [[2q0f]])' scene='53/536705/Cv/1'>
<StructureSection load='' size='350' side='right' caption='RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry [[2q0f]])' scene='53/536705/Cv/1'>
== Function ==
== Function ==
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'''RNA uridylyltransferase''' (RNAU) catalyzes the addition of uridine to RNA. RNAU acts as a suppressor of microRNA synthesis by mediating its terminal uridylation<ref>PMID:17189640</ref>. For additional details on RNAU-4 see [[Terminal Uridylyl Transferase]].
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'''RNA uridylyltransferase''' or '''terminal uridylyltransferase''' (RNAU) catalyzes the addition of uridine to RNA. RNAU acts as a suppressor of microRNA synthesis by mediating its terminal uridylation<ref>PMID:17189640</ref>. For additional details on RNAU-4 see [[Terminal Uridylyl Transferase]].
== Structural highlights ==
== Structural highlights ==

Revision as of 11:05, 8 March 2022

RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry 2q0f)

Drag the structure with the mouse to rotate

3D Structures of RNA uridylyltransferase

Updated on 08-March-2022

References

  1. ↑ Stagno J, Aphasizheva I, Rosengarth A, Luecke H, Aphasizhev R. UTP-bound and Apo structures of a minimal RNA uridylyltransferase. J Mol Biol. 2007 Feb 23;366(3):882-99. Epub 2006 Dec 2. PMID:17189640 doi:10.1016/j.jmb.2006.11.065
  2. ↑ Stagno J, Aphasizheva I, Aphasizhev R, Luecke H. Dual role of the RNA substrate in selectivity and catalysis by terminal uridylyl transferases. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14634-9. Epub 2007 Sep 4. PMID:17785418

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