Sandbox GGC12

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You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Function

Controls the host immune response system against pathogens through recognition of molecular patterns specific to microorganism. TLR3 is a nuclear-sensing TLR which is going to be activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.

Disease

A rare complication of human herpesvirus 1 (HHV-10 infection, occurring in only small minorities of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fear, headache, seizures, stupor, and often coma, frequently with a fatal outcome.

Relevance

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. of Crystal Structure of Fab12. Here is a name='78/781196/Ser212/2'>Zoomed out view</scene> which is important