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7ad0

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====
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==X-ray structure of Mdm2 with modified p53 peptide==
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<StructureSection load='7ad0' size='340' side='right'caption='[[7ad0]]' scene=''>
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<StructureSection load='7ad0' size='340' side='right'caption='[[7ad0]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7ad0]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AD0 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7ad0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ad0 OCA], [http://pdbe.org/7ad0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7ad0 RCSB], [http://www.ebi.ac.uk/pdbsum/7ad0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7ad0 ProSAT]</span></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9FB:(1~{S},2~{R})-2-azanylcyclopentane-1-carboxylic+acid'>9FB</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ad0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ad0 OCA], [https://pdbe.org/7ad0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ad0 RCSB], [https://www.ebi.ac.uk/pdbsum/7ad0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ad0 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.
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== Function ==
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[https://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and promotes it to proteasomal degradation.<ref>PMID:12821780</ref> <ref>PMID:15053880</ref> <ref>PMID:15195100</ref> <ref>PMID:16337594</ref> <ref>PMID:15632057</ref> <ref>PMID:17290220</ref> <ref>PMID:19098711</ref> <ref>PMID:19219073</ref> <ref>PMID:19965871</ref> <ref>PMID:20858735</ref> <ref>PMID:20173098</ref>
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==See Also==
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*[[MDM2 3D structures|MDM2 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Berlicki L]]
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[[Category: Dubin G]]
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[[Category: Fortuna P]]
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[[Category: Grudnik P]]
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[[Category: Holak TA]]
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[[Category: Twarda-Clapa A]]

Revision as of 06:21, 26 October 2022

X-ray structure of Mdm2 with modified p53 peptide

PDB ID 7ad0

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OCA

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