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6tj4

From Proteopedia

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Current revision

P. falciparum essential light chain, N-terminal domain

Structural highlights

6tj4 is a 2 chain structure with sequence from Plasmodium falciparum 3D7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.5Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q8IJM4_PLAF7

Publication Abstract from PubMed

Gliding, a type of motility based on an actin-myosin motor, is specific to apicomplexan parasites. Myosin A binds two light chains which further interact with glideosome associated proteins and assemble into the glideosome. The role of individual glideosome proteins is unclear due to the lack of structures of larger glideosome assemblies. Here, we investigate the role of essential light chains (ELCs) in Toxoplasma gondii and Plasmodium falciparum and present their crystal structures as part of trimeric sub-complexes. We show that although ELCs bind a conserved MyoA sequence, P. falciparum ELC adopts a distinct structure in the free and MyoA-bound state. We suggest that ELCs enhance MyoA performance by inducing secondary structure in MyoA and thus stiffen its lever arm. Structural and biophysical analysis reveals that calcium binding has no influence on the structure of ELCs. Our work represents a further step towards understanding the mechanism of gliding in Apicomplexa.

Structural role of essential light chains in the apicomplexan glideosome.,Pazicky S, Dhamotharan K, Kaszuba K, Mertens HDT, Gilberger T, Svergun D, Kosinski J, Weininger U, Low C Commun Biol. 2020 Oct 13;3(1):568. doi: 10.1038/s42003-020-01283-8. PMID:33051581^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Pazicky S, Dhamotharan K, Kaszuba K, Mertens HDT, Gilberger T, Svergun D, Kosinski J, Weininger U, Low C. Structural role of essential light chains in the apicomplexan glideosome. Commun Biol. 2020 Oct 13;3(1):568. doi: 10.1038/s42003-020-01283-8. PMID:33051581 doi:http://dx.doi.org/10.1038/s42003-020-01283-8

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6tj4"

Categories: Large Structures | Plasmodium falciparum 3D7 | Loew C | Pazicky S

@@ Line 3: / Line 3: @@
 <StructureSection load='6tj4' size='340' side='right'caption='[[6tj4]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6tj4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TJ4 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6tj4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TJ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TJ4 FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PF3D7_1017500 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tj4 OCA], [http://pdbe.org/6tj4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tj4 RCSB], [http://www.ebi.ac.uk/pdbsum/6tj4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tj4 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tj4 OCA], [https://pdbe.org/6tj4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tj4 RCSB], [https://www.ebi.ac.uk/pdbsum/6tj4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tj4 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q8IJM4_PLAF7 Q8IJM4_PLAF7]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 16: / Line 18: @@
 </div>
 <div class="pdbe-citations 6tj4" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Myosin 3D Structures|Myosin 3D Structures]]
 == References ==
 <references/>
@@ Line 21: / Line 26: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Plaf7]]
+[[Category: Plasmodium falciparum 3D7]]
-[[Category: Loew, C]]
+[[Category: Loew C]]
-[[Category: Pazicky, S]]
+[[Category: Pazicky S]]
-[[Category: Essential light chain]]
-[[Category: Glideosome]]
-[[Category: Motility]]
-[[Category: Motor protein]]
-[[Category: Myosin]]

6tj4

From Proteopedia

Current revision

P. falciparum essential light chain, N-terminal domain

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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