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6wqr
From Proteopedia
(Difference between revisions)
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==NMR solution structure of leech peptide HSTX-I== | ==NMR solution structure of leech peptide HSTX-I== | ||
| - | <StructureSection load='6wqr' size='340' side='right'caption='[[6wqr | + | <StructureSection load='6wqr' size='340' side='right'caption='[[6wqr]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6wqr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WQR OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6wqr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemadipsa_sylvestris Haemadipsa sylvestris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WQR FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wqr OCA], [https://pdbe.org/6wqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wqr RCSB], [https://www.ebi.ac.uk/pdbsum/6wqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wqr ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HSTX1_HAESL HSTX1_HAESL] Leech salivary gland peptide with unknown function (PubMed:32524995). It was originally described as exhibiting analgesic function by specifically inhibiting rodent Nav1.8/SCN10A and Nav1.9/SCN11A voltage-gated sodium channels, as well as showing analgesic activities in several mouse models (PubMed:29559913). In a second study, the synthetic peptide has been shown as having very weak activity on Nav1.8/SCN10A at the highest concentration tested (90 uM) and as being only very modestly active at hNav1.9/SCN11A, with a modest peak current size reduction (~19%) at high concentrations (10 uM) (PubMed:32524995). In addition, this second study reports no analgesic activity in a mouse model of inflammatory pain (PubMed:32524995).<ref>PMID:29559913</ref> <ref>PMID:32524995</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Haemadipsa sylvestris]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: McMahon | + | [[Category: McMahon KL]] |
| - | [[Category: Schroeder | + | [[Category: Schroeder CI]] |
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Current revision
NMR solution structure of leech peptide HSTX-I
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