1cy9

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[[Image:1cy9.gif|left|200px]]
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{{Seed}}
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[[Image:1cy9.png|left|200px]]
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{{STRUCTURE_1cy9| PDB=1cy9 | SCENE= }}
{{STRUCTURE_1cy9| PDB=1cy9 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE 30 KDA FRAGMENT OF E. COLI DNA TOPOISOMERASE I. MONOCLINIC FORM'''
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===CRYSTAL STRUCTURE OF THE 30 KDA FRAGMENT OF E. COLI DNA TOPOISOMERASE I. MONOCLINIC FORM===
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==Overview==
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DNA topoisomerases are the enzymes responsible for maintaining the topological states of DNA. In order to change the topology of DNA, topoisomerases pass one or two DNA strands through transient single or double strand breaks in the DNA phosphodiester backbone. It has been proposed that both type IA and type II enzymes change conformation dramatically during the reaction cycle in order to accomplish these transformations. In the case of Escherichia coli DNA topoisomerase I, it has been suggested that a 30 kDa fragment moves away from the rest of the protein to create an entrance into the central hole in the protein. Structures of the 30 kDa fragment reveal that indeed this fragment can change conformation significantly. The fragment is composed of two domains, and while the domains themselves remain largely unchanged, their relative arrangement can change dramatically.
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(as it appears on PubMed at http://www.pubmed.gov), where 10504724 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10504724}}
==About this Structure==
==About this Structure==
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[[Category: Decatenating enzyme]]
[[Category: Decatenating enzyme]]
[[Category: Dna topoisomerase]]
[[Category: Dna topoisomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:14:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:46:42 2008''

Revision as of 18:46, 30 June 2008

Image:1cy9.png

Template:STRUCTURE 1cy9

CRYSTAL STRUCTURE OF THE 30 KDA FRAGMENT OF E. COLI DNA TOPOISOMERASE I. MONOCLINIC FORM

Template:ABSTRACT PUBMED 10504724

About this Structure

1CY9 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Conformational changes in E. coli DNA topoisomerase I., Feinberg H, Lima CD, Mondragon A, Nat Struct Biol. 1999 Oct;6(10):918-22. PMID:10504724

Page seeded by OCA on Mon Jun 30 21:46:42 2008

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