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6tlz
From Proteopedia
(Difference between revisions)
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| - | == | + | ==N-Domain P40/P90 Mycoplasma pneumoniae complexed with 3'SL== |
| - | <StructureSection load='6tlz' size='340' side='right'caption='[[6tlz]]' scene=''> | + | <StructureSection load='6tlz' size='340' side='right'caption='[[6tlz]], [[Resolution|resolution]] 3.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TLZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TLZ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6tlz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycpn Mycpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TLZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TLZ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tlz OCA], [http://pdbe.org/6tlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tlz RCSB], [http://www.ebi.ac.uk/pdbsum/6tlz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tlz ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MPN_142, MP012 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272634 MYCPN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tlz OCA], [http://pdbe.org/6tlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tlz RCSB], [http://www.ebi.ac.uk/pdbsum/6tlz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tlz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Mycoplasma pneumoniae is a bacterial human pathogen that causes primary atypical pneumonia. M. pneumoniae motility and infectivity are mediated by the immunodominant proteins P1 and P40/P90, which form a transmembrane adhesion complex. Here we report the structure of P1, determined by X-ray crystallography and cryo-electron microscopy, and the X-ray structure of P40/P90. Contrary to what had been suggested, the binding site for sialic acid was found in P40/P90 and not in P1. Genetic and clinical variability concentrates on the N-terminal domain surfaces of P1 and P40/P90. Polyclonal antibodies generated against the mostly conserved C-terminal domain of P1 inhibited adhesion of M. pneumoniae, and serology assays with sera from infected patients were positive when tested against this C-terminal domain. P40/P90 also showed strong reactivity against human infected sera. The architectural elements determined for P1 and P40/P90 open new possibilities in vaccine development against M. pneumoniae infections. | ||
| + | |||
| + | Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae.,Vizarraga D, Kawamoto A, Matsumoto U, Illanes R, Perez-Luque R, Martin J, Mazzolini R, Bierge P, Pich OQ, Espasa M, Sanfeliu I, Esperalba J, Fernandez-Huerta M, Scheffer MP, Pinyol J, Frangakis AS, Lluch-Senar M, Mori S, Shibayama K, Kenri T, Kato T, Namba K, Fita I, Miyata M, Aparicio D Nat Commun. 2020 Oct 14;11(1):5188. doi: 10.1038/s41467-020-18777-y. PMID:33057023<ref>PMID:33057023</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6tlz" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Aparicio D]] | + | [[Category: Mycpn]] |
| - | [[Category: Fita I]] | + | [[Category: Aparicio, D]] |
| - | [[Category: Illanes R]] | + | [[Category: Fita, I]] |
| - | [[Category: Martin J]] | + | [[Category: Illanes, R]] |
| - | [[Category: Perez-Luque R]] | + | [[Category: Martin, J]] |
| - | [[Category: Vizarraga D]] | + | [[Category: Perez-Luque, R]] |
| + | [[Category: Vizarraga, D]] | ||
| + | [[Category: Adhesion]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Extracellular]] | ||
| + | [[Category: Sugar]] | ||
Revision as of 09:50, 18 November 2020
N-Domain P40/P90 Mycoplasma pneumoniae complexed with 3'SL
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Categories: Large Structures | Mycpn | Aparicio, D | Fita, I | Illanes, R | Martin, J | Perez-Luque, R | Vizarraga, D | Adhesion | Cell adhesion | Extracellular | Sugar
