6w58

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Current revision (14:41, 6 March 2024) (edit) (undo)
 
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==hPGDS complexed with an aza-quinoline==
==hPGDS complexed with an aza-quinoline==
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<StructureSection load='6w58' size='340' side='right'caption='[[6w58]]' scene=''>
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<StructureSection load='6w58' size='340' side='right'caption='[[6w58]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W58 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6W58 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6w58]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W58 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W58 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6w58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w58 OCA], [http://pdbe.org/6w58 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6w58 RCSB], [http://www.ebi.ac.uk/pdbsum/6w58 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6w58 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.395&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SWS:7-(azetidin-1-yl)-~{N}-[4-(2-oxidanylpropan-2-yl)cyclohexyl]-1,6-naphthyridine-3-carboxamide'>SWS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w58 OCA], [https://pdbe.org/6w58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w58 RCSB], [https://www.ebi.ac.uk/pdbsum/6w58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w58 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>
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==See Also==
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Elkins PA]]
[[Category: Elkins PA]]
[[Category: Ward P]]
[[Category: Ward P]]

Current revision

hPGDS complexed with an aza-quinoline

PDB ID 6w58

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