4bfd

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<StructureSection load='4bfd' size='340' side='right'caption='[[4bfd]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4bfd' size='340' side='right'caption='[[4bfd]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bfd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4BFD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bfd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BFD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8T3:N-[3-[(1S,3S,6S)-5-AZANYL-3-METHYL-4-AZABICYCLO[4.1.0]HEPT-4-EN-3-YL]-4-FLUORANYL-PHENYL]-5-CHLORANYL-PYRIDINE-2-CARBOXAMIDE'>8T3</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8T3:N-[3-[(1S,3S,6S)-5-AZANYL-3-METHYL-4-AZABICYCLO[4.1.0]HEPT-4-EN-3-YL]-4-FLUORANYL-PHENYL]-5-CHLORANYL-PYRIDINE-2-CARBOXAMIDE'>8T3</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bek|4bek]], [[4bel|4bel]], [[4bfb|4bfb]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bek|4bek]], [[4bel|4bel]], [[4bfb|4bfb]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4bfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfd OCA], [http://pdbe.org/4bfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bfd RCSB], [http://www.ebi.ac.uk/pdbsum/4bfd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfd OCA], [https://pdbe.org/4bfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bfd RCSB], [https://www.ebi.ac.uk/pdbsum/4bfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 07:11, 31 August 2022

CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND

PDB ID 4bfd

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