Sandbox Reserved 1628

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Adhesins are used for binding cells together, commonly found helping pathogens bind to host cells. This specific adhesin has a ligand of <scene name='86/861610/Ligandhighlight/1'>beta-D-galactopyranose-(1,3)-beta-D-glucopyranose.</scene> <scene name='86/861610/Bdglacbdglc/2'>A close up view of just the sugar ligand.</scene> <scene name='86/861610/Ligandandactivelabel/2'>This shows how the ligand and active site interact.</scene>
Adhesins are used for binding cells together, commonly found helping pathogens bind to host cells. This specific adhesin has a ligand of <scene name='86/861610/Ligandhighlight/1'>beta-D-galactopyranose-(1,3)-beta-D-glucopyranose.</scene> <scene name='86/861610/Bdglacbdglc/2'>A close up view of just the sugar ligand.</scene> <scene name='86/861610/Ligandandactivelabel/2'>This shows how the ligand and active site interact.</scene>
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The protein is mainly made of antiparallel beta sheets, with the loops connecting the sheets making up the most critical parts of the active site. Two loops responsible for binding to the calcium ion, CBL1 and CLB2, are closer to the rest of the protein, and loops L1-L3 are further out - some of these loops are highly conserved between different adhesins, some are very variable.
== Biological relevance and broader implications ==
== Biological relevance and broader implications ==

Revision as of 01:19, 9 November 2020

This Sandbox is Reserved from 09/18/2020 through 03/20/2021 for use in CHEM 351 Biochemistry taught by Bonnie Hall at Grand View University, Des Moines, IA. This reservation includes Sandbox Reserved 1628 through Sandbox Reserved 1642.
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References

[3]

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ Hoffmann D, Diderrich R, Reithofer V, Friederichs S, Kock M, Essen LO, Mosch HU. Functional reprogramming of Candida glabrata epithelial adhesins: the role of conserved and variable structural motifs in ligand binding. J Biol Chem. 2020 Jul 15. pii: RA120.013968. doi: 10.1074/jbc.RA120.013968. PMID:32669365 doi:http://dx.doi.org/10.1074/jbc.RA120.013968
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