Spindlin

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**[[4mzg]], [[4mzh]], [[4mzf]], [[4h75]], [[5y5w]], [[7bqz]], [[7bu9]] – hSPIN1 + histone peptide <br />
**[[4mzg]], [[4mzh]], [[4mzf]], [[4h75]], [[5y5w]], [[7bqz]], [[7bu9]] – hSPIN1 + histone peptide <br />
**[[5jsg]], [[5jsj]], [[6i8b]], [[6i8l]], [[6i8y]], [[6qpl]] – hSPIN1 + inhibitor <br />
**[[5jsg]], [[5jsj]], [[6i8b]], [[6i8l]], [[6i8y]], [[6qpl]] – hSPIN1 + inhibitor <br />
 +
**[[7cna]] – hSPIN1 + SPIN-DOC + inhibitor <br />
*Spindlin-2B
*Spindlin-2B

Revision as of 07:19, 10 April 2022

Human spindlin-1 (skyblue) complex with histone H3 peptide (wheat) containing trimethyl lysine, MPD, Mg+2 (green) and Cl- (green) ions (PDB code 4mzg)

Drag the structure with the mouse to rotate

3D Structures of spindlin

Updated on 10-April-2022

References

  1. ↑ Wang W, Chen Z, Mao Z, Zhang H, Ding X, Chen S, Zhang X, Xu R, Zhu B. Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes. EMBO Rep. 2011 Oct 28;12(11):1160-6. doi: 10.1038/embor.2011.184. PMID:21960006 doi:http://dx.doi.org/10.1038/embor.2011.184
  2. ↑ Franz H, Greschik H, Willmann D, Ozretic L, Jilg CA, Wardelmann E, Jung M, Buettner R, Schule R. The histone code reader SPIN1 controls RET signaling in liposarcoma. Oncotarget. 2015 Mar 10;6(7):4773-89. doi: 10.18632/oncotarget.3000. PMID:25749382 doi:http://dx.doi.org/10.18632/oncotarget.3000
  3. ↑ Su X, Zhu G, Ding X, Lee SY, Dou Y, Zhu B, Wu W, Li H. Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1. Genes Dev. 2014 Mar 15;28(6):622-36. doi: 10.1101/gad.233239.113. Epub 2014 Mar, 3. PMID:24589551 doi:http://dx.doi.org/10.1101/gad.233239.113

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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