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Sandbox GGC12
From Proteopedia
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Controls the host immune response system against pathogens through recognition of molecular patterns specific to microorganism. TLR3 is a nuclear-sensing TLR which is going to be activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. | Controls the host immune response system against pathogens through recognition of molecular patterns specific to microorganism. TLR3 is a nuclear-sensing TLR which is going to be activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. | ||
== Disease == | == Disease == | ||
| - | A rare complication of human herpesvirus 1 (HHV- | + | A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only small minorities of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fear, headache, seizures, stupor, and often coma, frequently with a fatal outcome. |
== Relevance == | == Relevance == | ||
Revision as of 18:05, 9 November 2020
Crystal Structure of Fab12
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References
- ↑ Luo J, Obmolova G, Malia TJ, Wu SJ, Duffy KE, Marion JD, Bell JK, Ge P, Zhou ZH, Teplyakov A, Zhao Y, Lamb RJ, Jordan JL, San Mateo LR, Sweet RW, Gilliland GL. Lateral Clustering of TLR3:dsRNA Signaling Units Revealed by TLR3ecd:3Fabs Quaternary Structure. J Mol Biol. 2012 May 9. PMID:22579623 doi:10.1016/j.jmb.2012.05.006
- ↑ Luo J, Obmolova G, Malia TJ, Wu SJ, Duffy KE, Marion JD, Bell JK, Ge P, Zhou ZH, Teplyakov A, Zhao Y, Lamb RJ, Jordan JL, San Mateo LR, Sweet RW, Gilliland GL. Lateral Clustering of TLR3:dsRNA Signaling Units Revealed by TLR3ecd:3Fabs Quaternary Structure. J Mol Biol. 2012 May 9. PMID:22579623 doi:10.1016/j.jmb.2012.05.006
