6kyp

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==A transcription factor==
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==X-ray structure of human PPARalpha ligand binding domain-GW9662-clofibric acid co-crystals obtained by delipidation and co-crystallization==
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<StructureSection load='6kyp' size='340' side='right'caption='[[6kyp]]' scene=''>
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<StructureSection load='6kyp' size='340' side='right'caption='[[6kyp]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KYP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KYP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6kyp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KYP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KYP FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kyp OCA], [http://pdbe.org/6kyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kyp RCSB], [http://www.ebi.ac.uk/pdbsum/6kyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kyp ProSAT]</span></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E0O:2-(4-chloranylphenoxy)-2-methyl-propanoic+acid'>E0O</scene>, <scene name='pdbligand=GW9:2-CHLORO-5-NITRO-N-PHENYLBENZAMIDE'>GW9</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kyp OCA], [http://pdbe.org/6kyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kyp RCSB], [http://www.ebi.ac.uk/pdbsum/6kyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kyp ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN]] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Honda A]]
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[[Category: Honda, A]]
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[[Category: Ishii I]]
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[[Category: Ishii, I]]
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[[Category: Ishikawa R]]
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[[Category: Ishikawa, R]]
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[[Category: Kamata S]]
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[[Category: Kamata, S]]
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[[Category: Oyama T]]
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[[Category: Oyama, T]]
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[[Category: Saito K]]
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[[Category: Saito, K]]
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[[Category: Nuclear receptor]]
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[[Category: Ppar]]
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[[Category: Protein-ligand complex]]
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[[Category: Transcription]]

Revision as of 07:05, 25 November 2020

X-ray structure of human PPARalpha ligand binding domain-GW9662-clofibric acid co-crystals obtained by delipidation and co-crystallization

PDB ID 6kyp

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OCA

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