1d0n

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[[Image:1d0n.jpg|left|200px]]
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{{Seed}}
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[[Image:1d0n.png|left|200px]]
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{{STRUCTURE_1d0n| PDB=1d0n | SCENE= }}
{{STRUCTURE_1d0n| PDB=1d0n | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF CALCIUM-FREE EQUINE PLASMA GELSOLIN.'''
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===THE CRYSTAL STRUCTURE OF CALCIUM-FREE EQUINE PLASMA GELSOLIN.===
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==Overview==
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The structure of gelsolin has been determined by crystallography and comprises six structurally related domains that, in a Ca2+-free environment, pack together to form a compact globular structure in which the putative actin-binding sequences are not sufficiently exposed to enable binding to occur. We propose that binding Ca2+ can release the connections that join the N- and C-terminal halves of gelsolin, enabling each half to bind actin relatively independently. Domain shifts are proposed in response to Ca2+ as bases for models of how gelsolin acts to sever, cap, or nucleate F-actin filaments. The structure also invites discussion of polyphosphoinositide binding to segment 2 and suggests how mutation at Asp-187 could initiate a series of events that lead to deposition of amyloid plaques, as observed in victims of familial amyloidosis (Finnish type).
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The line below this paragraph, {{ABSTRACT_PUBMED_9288746}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9288746 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9288746}}
==About this Structure==
==About this Structure==
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[[Category: Mixed alpha-beta structure]]
[[Category: Mixed alpha-beta structure]]
[[Category: Protein domain packing]]
[[Category: Protein domain packing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:19:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:57:27 2008''

Revision as of 18:57, 30 June 2008

Image:1d0n.png

Template:STRUCTURE 1d0n

THE CRYSTAL STRUCTURE OF CALCIUM-FREE EQUINE PLASMA GELSOLIN.

Template:ABSTRACT PUBMED 9288746

About this Structure

1D0N is a Single protein structure of sequence from Equus caballus. Full crystallographic information is available from OCA.

Reference

The crystal structure of plasma gelsolin: implications for actin severing, capping, and nucleation., Burtnick LD, Koepf EK, Grimes J, Jones EY, Stuart DI, McLaughlin PJ, Robinson RC, Cell. 1997 Aug 22;90(4):661-70. PMID:9288746

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