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6bnh

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Current revision (10:38, 14 June 2023) (edit) (undo)
 
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==Solution NMR structures of BRD4 ET domain with JMJD6 peptide==
==Solution NMR structures of BRD4 ET domain with JMJD6 peptide==
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<StructureSection load='6bnh' size='340' side='right'caption='[[6bnh]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='6bnh' size='340' side='right'caption='[[6bnh]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6bnh]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BNH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6BNH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6bnh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BNH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BNH FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6bnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bnh OCA], [http://pdbe.org/6bnh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bnh RCSB], [http://www.ebi.ac.uk/pdbsum/6bnh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bnh ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bnh OCA], [https://pdbe.org/6bnh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bnh RCSB], [https://www.ebi.ac.uk/pdbsum/6bnh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bnh ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). [[http://www.uniprot.org/uniprot/JMJD6_HUMAN JMJD6_HUMAN]] Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.<ref>PMID:17947579</ref> <ref>PMID:19574390</ref> <ref>PMID:21060799</ref> <ref>PMID:20684070</ref> <ref>PMID:20679243</ref>
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ju, Y]]
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[[Category: Ju Y]]
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[[Category: Konuma, T]]
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[[Category: Konuma T]]
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[[Category: Ren, C]]
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[[Category: Ren C]]
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[[Category: Sharma, R]]
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[[Category: Sharma R]]
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[[Category: Yu, D]]
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[[Category: Yu D]]
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[[Category: Zeng, L]]
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[[Category: Zeng L]]
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[[Category: Zhang, Q]]
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[[Category: Zhang Q]]
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[[Category: Zhao, C]]
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[[Category: Zhao C]]
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[[Category: Zhou, M M]]
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[[Category: Zhou M-M]]
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[[Category: Bet]]
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[[Category: Complex]]
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[[Category: Rna]]
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[[Category: Transcription-oxidoreductase complex]]
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Current revision

Solution NMR structures of BRD4 ET domain with JMJD6 peptide

PDB ID 6bnh

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