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6c8r

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Current revision (14:58, 4 October 2023) (edit) (undo)
 
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<StructureSection load='6c8r' size='340' side='right'caption='[[6c8r]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='6c8r' size='340' side='right'caption='[[6c8r]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6c8r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Catro Catro]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C8R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6C8R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6c8r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Catharanthus_roseus Catharanthus roseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C8R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EQV:Loganic+acid'>EQV</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.951&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6c8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c8r OCA], [http://pdbe.org/6c8r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c8r RCSB], [http://www.ebi.ac.uk/pdbsum/6c8r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c8r ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EQV:Loganic+acid'>EQV</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c8r OCA], [https://pdbe.org/6c8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c8r RCSB], [https://www.ebi.ac.uk/pdbsum/6c8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c8r ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LAMT_CATRO LAMT_CATRO] Component of the seco-iridoid and derivatives monoterpenoid indole alkaloids (MIAs, e.g. vinblastine and ajmalicine) biosynthesis pathway. Catalyzes the methylation of loganic acid (6S,7R) to produce loganin (PubMed:29399933, PubMed:18326827, PubMed:24104568). Weak activity with secologanic acid as substrate. Inactive on deoxyloganic, dehydrologanic, epiloganic and loganetic acid (PubMed:18326827).<ref>PMID:18326827</ref> <ref>PMID:24104568</ref> <ref>PMID:29399933</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Catro]]
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[[Category: Catharanthus roseus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Nair, S K]]
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[[Category: Nair SK]]
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[[Category: Petronikolou, N]]
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[[Category: Petronikolou N]]
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[[Category: Loganic acid]]
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[[Category: Methyltransferase]]
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[[Category: Sabath]]
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[[Category: Transferase]]
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Current revision

Loganic acid O-methyltransferase complexed with SAH and loganic acid

PDB ID 6c8r

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OCA

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