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6cby

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Current revision (00:56, 28 December 2023) (edit) (undo)
 
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<StructureSection load='6cby' size='340' side='right'caption='[[6cby]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
<StructureSection load='6cby' size='340' side='right'caption='[[6cby]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6cby]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CBY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6CBY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6cby]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CBY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EW4:[3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)-3-methylazetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl)-1H-pyrrol-3-yl]methanone'>EW4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6cby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cby OCA], [http://pdbe.org/6cby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cby RCSB], [http://www.ebi.ac.uk/pdbsum/6cby PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cby ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EW4:[3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)-3-methylazetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl)-1H-pyrrol-3-yl]methanone'>EW4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cby OCA], [https://pdbe.org/6cby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cby RCSB], [https://www.ebi.ac.uk/pdbsum/6cby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cby ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN]] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref>
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[https://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: BROWN, P J]]
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[[Category: BROWN PJ]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Casimiro-Garcia, A]]
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[[Category: Casimiro-Garcia A]]
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[[Category: DONG, A]]
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[[Category: DONG A]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: Hutchinson, A]]
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[[Category: Hutchinson A]]
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[[Category: KUMPF, R]]
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[[Category: KUMPF R]]
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[[Category: OWEN, A]]
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[[Category: OWEN A]]
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[[Category: Structural genomic]]
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[[Category: Seitova A]]
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[[Category: Seitova, A]]
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[[Category: TATLOCK J]]
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[[Category: TATLOCK, J]]
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[[Category: TAYLOR A]]
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[[Category: TAYLOR, A]]
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[[Category: WU H]]
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[[Category: WU, H]]
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[[Category: ZENG H]]
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[[Category: ZENG, H]]
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[[Category: Sgc]]
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[[Category: Smyd2 mtf9975 inhibitor]]
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[[Category: Transferase-inhibitor complex]]
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Current revision

Crystal structure of human SET and MYND Domain Containing protein 2 with MTF9975

PDB ID 6cby

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