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6czs

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Current revision (15:14, 4 October 2023) (edit) (undo)
 
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<StructureSection load='6czs' size='340' side='right'caption='[[6czs]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
<StructureSection load='6czs' size='340' side='right'caption='[[6czs]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6czs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CZS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6CZS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6czs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CZS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSH, CPSB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900006:trehalose'>PRD_900006</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_H Cathepsin H], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.16 3.4.22.16] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6czs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6czs OCA], [https://pdbe.org/6czs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6czs RCSB], [https://www.ebi.ac.uk/pdbsum/6czs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6czs ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6czs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6czs OCA], [http://pdbe.org/6czs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6czs RCSB], [http://www.ebi.ac.uk/pdbsum/6czs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6czs ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/CATH_HUMAN CATH_HUMAN]] Narcolepsy-cataplexy.
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[https://www.uniprot.org/uniprot/CATH_HUMAN CATH_HUMAN] Narcolepsy-cataplexy.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CATH_HUMAN CATH_HUMAN]] Important for the overall degradation of proteins in lysosomes.
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[https://www.uniprot.org/uniprot/CATH_HUMAN CATH_HUMAN] Important for the overall degradation of proteins in lysosomes.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cathepsin H]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hao, Y]]
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[[Category: Hao Y]]
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[[Category: Huang, X]]
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[[Category: Huang X]]
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[[Category: Hydrolase]]
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[[Category: Inhibitory prodomain]]
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[[Category: Papain family cysteine peptidase]]
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[[Category: Protein degradation in lysosome]]
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Current revision

Crystal structure of human pro-cathepsin H C26S mutant

PDB ID 6czs

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