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6d4f

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Current revision (15:17, 4 October 2023) (edit) (undo)
 
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<StructureSection load='6d4f' size='340' side='right'caption='[[6d4f]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
<StructureSection load='6d4f' size='340' side='right'caption='[[6d4f]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6d4f]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D4F OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6D4F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6d4f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D4F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.909&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6d4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d4f OCA], [http://pdbe.org/6d4f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d4f RCSB], [http://www.ebi.ac.uk/pdbsum/6d4f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d4f ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d4f OCA], [https://pdbe.org/6d4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d4f RCSB], [https://www.ebi.ac.uk/pdbsum/6d4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d4f ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTPRE_HUMAN PTPRE_HUMAN]] Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity). Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).
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[https://www.uniprot.org/uniprot/PTPRE_HUMAN PTPRE_HUMAN] Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity). Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Austin BP]]
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[[Category: Austin, B P]]
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[[Category: Burke Jr TR]]
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[[Category: Burke, T R]]
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[[Category: Dyas BK]]
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[[Category: Dyas, B K]]
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[[Category: Lountos GT]]
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[[Category: Lountos, G T]]
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[[Category: Raran-Kurussi S]]
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[[Category: Raran-Kurussi, S]]
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[[Category: Ulrich RG]]
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[[Category: Ulrich, R G]]
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[[Category: Waugh DS]]
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[[Category: Waugh, D S]]
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[[Category: Zhao BM]]
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[[Category: Zhao, B M]]
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[[Category: Hydrolase]]
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[[Category: Phosphatase]]
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Current revision

Crystal structure of PTP epsilon D2 domain (A455N/V457Y/E597D)

PDB ID 6d4f

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