6ej1

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Current revision (12:35, 6 November 2024) (edit) (undo)
 
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<StructureSection load='6ej1' size='340' side='right'caption='[[6ej1]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
<StructureSection load='6ej1' size='340' side='right'caption='[[6ej1]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ej1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EJ1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6EJ1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ej1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EJ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EJ1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B7Q:5-[1-[1-(2-chloranylethanoyl)piperidin-4-yl]pyrazol-4-yl]-7-oxidanylidene-6-propan-2-yl-4~{H}-pyrazolo[1,5-a]pyrimidine-3-carbonitrile'>B7Q</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ej1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ej1 OCA], [http://pdbe.org/6ej1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ej1 RCSB], [http://www.ebi.ac.uk/pdbsum/6ej1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ej1 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B7Q:5-[1-[1-(2-chloranylethanoyl)piperidin-4-yl]pyrazol-4-yl]-7-oxidanylidene-6-propan-2-yl-4~{H}-pyrazolo[1,5-a]pyrimidine-3-carbonitrile'>B7Q</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ej1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ej1 OCA], [https://pdbe.org/6ej1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ej1 RCSB], [https://www.ebi.ac.uk/pdbsum/6ej1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ej1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
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[https://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Burgess-Brown, N A]]
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[[Category: Burgess-Brown NA]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Huber K]]
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[[Category: Huber, K]]
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[[Category: Kupinska K]]
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[[Category: Kupinska, K]]
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[[Category: Newman JA]]
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[[Category: Newman, J A]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U]]
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[[Category: Ruda GF]]
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[[Category: Ruda, G F]]
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[[Category: Srikannathasan V]]
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[[Category: Srikannathasan, V]]
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[[Category: Strain-Damerell C]]
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[[Category: Strain-Damerell, C]]
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[[Category: Szykowska A]]
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[[Category: Szykowska, A]]
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[[Category: Vazquez-Rodriguez SA]]
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[[Category: Vazquez-Rodriguez, S A]]
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[[Category: Wright M]]
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[[Category: Wright, M]]
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[[Category: Von Delft F]]
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[[Category: Kdm5b lysine specific demethylase]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of KDM5B in complex with KDOPZ48a.

PDB ID 6ej1

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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