Sandbox GGC6

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You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Function

protease thrombin cleaves fibrinogen into monomers. The formation of monomers, fibrinogen beta, and fibrinogen alpha is insoluble fibrin matrix. fibrin works as a binding or trapping agent in the coagulation process, which creates blood clot.

For small wounds, the polymerized fibrin with platelets forms a hemostatic plug over the wounds site. Fibrin is also anti inflammatory which it protects against IFNG- mediated hemorrhage.

Afibrinogenemic pregnant patients will result in spontaneous miscarriage. Fibrinogen supplemental will allow the patients to sustain the pregnancy, therefore, maternal fibrinogen plays a important role for successful pregnancy.^[3]

Disease

Congenital afibrinogenemia (CAFBN)

This is an inherited blood disorder where the blood does not clot normally. This disease is cause by truncating mutations. Changing in position arg-35

when thrombin cleaves the site of fibrinopeptide leads to alpha- dysfibrinogenemias.

Relevance

Structural highlights

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