1d1r

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[[Image:1d1r.gif|left|200px]]
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{{STRUCTURE_1d1r| PDB=1d1r | SCENE= }}
{{STRUCTURE_1d1r| PDB=1d1r | SCENE= }}
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'''NMR SOLUTION STRUCTURE OF THE PRODUCT OF THE E. COLI YCIH GENE.'''
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===NMR SOLUTION STRUCTURE OF THE PRODUCT OF THE E. COLI YCIH GENE.===
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==Overview==
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Structural genomics presents an enormous challenge with up to 100 000 protein targets in the human genome alone. At current rates of structure deter-mination, judicious selection of targets is necessary. Here, a phylogenetic approach to target selection is described which makes use of the National Center for Biotechnology Information database of Clusters of Orthologous Groups (COGS). The strategy is designed so that each new protein structure is likely to provide novel sequence-fold information. To demonstrate this approach, the NMR solution structure of YciH (COG0023), a putative translation initiation factor from Escherichia coli, has been determined and its fold classified. YciH is an ortholog of eIF-1/SUI1, an integral component of the translation initiation complex in eukaryotes. The structure consists of two antiparallel alpha-helices packed against the same side of a five-stranded beta-sheet. The first 31 residues of the 11.5 kDa protein are unstructured in solution. Comparative analysis indicates that the folded portion of YciH resembles a number of structures with the alpha-beta plait topology, though its sequence is not homologous to any of them. Thus, the phylogenetic approach to target selection described here was used successfully to identify a new homologous superfamily within this topology.
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(as it appears on PubMed at http://www.pubmed.gov), where 10497266 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10497266}}
==About this Structure==
==About this Structure==
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1D1R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1R OCA].
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1D1R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1R OCA].
==Reference==
==Reference==
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[[Category: Ferredoxin-like fold]]
[[Category: Ferredoxin-like fold]]
[[Category: Open-faced beta sandwich]]
[[Category: Open-faced beta sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:21:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:06:57 2008''

Revision as of 19:07, 30 June 2008

Image:1d1r.png

Template:STRUCTURE 1d1r

NMR SOLUTION STRUCTURE OF THE PRODUCT OF THE E. COLI YCIH GENE.

Template:ABSTRACT PUBMED 10497266

About this Structure

1D1R is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

A phylogenetic approach to target selection for structural genomics: solution structure of YciH., Cort JR, Koonin EV, Bash PA, Kennedy MA, Nucleic Acids Res. 1999 Oct 15;27(20):4018-27. PMID:10497266

Page seeded by OCA on Mon Jun 30 22:06:57 2008

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