1d24

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{{STRUCTURE_1d24| PDB=1d24 | SCENE= }}
{{STRUCTURE_1d24| PDB=1d24 | SCENE= }}
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'''CRYSTAL AND MOLECULAR STRUCTURE OF A DNA DUPLEX CONTAINING THE CARCINOGENIC LESION O6-METHYLGUANINE'''
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===CRYSTAL AND MOLECULAR STRUCTURE OF A DNA DUPLEX CONTAINING THE CARCINOGENIC LESION O6-METHYLGUANINE===
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==Overview==
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The crystal and molecular structure of the first DNA duplex containing the carcinogenic lesion O6MeG has been determined to a resolution of 1.9 A and refined to an R factor of 19%. (d[CGC-(O6Me)GCG])2 crystallizes in the left-handed Z DNA form and has crystal parameters and conformational features similar to those of the parent sequence [d(CG)3]2. The methyl groups on O6 of G4 and G10 have C5-C6-O6-O6Me torsion angles of 73 degrees and 56 degrees, respectively, and protrude onto the major groove surface. The base-pairing conformation for the methylated G.C base pairs is of the Watson-Crick type as opposed to a wobble-type conformation that had been proposed in a B DNA fragment. As in other Z DNA structures, a spine of hydration is seen in the minor groove.
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(as it appears on PubMed at http://www.pubmed.gov), where 2271657 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2271657}}
==About this Structure==
==About this Structure==
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[[Category: Modified]]
[[Category: Modified]]
[[Category: Z-dna]]
[[Category: Z-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:21:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:09:55 2008''

Revision as of 19:10, 30 June 2008

Image:1d24.png

Template:STRUCTURE 1d24

CRYSTAL AND MOLECULAR STRUCTURE OF A DNA DUPLEX CONTAINING THE CARCINOGENIC LESION O6-METHYLGUANINE

Template:ABSTRACT PUBMED 2271657

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal and molecular structure of a DNA duplex containing the carcinogenic lesion O6-methylguanine., Ginell SL, Kuzmich S, Jones RA, Berman HM, Biochemistry. 1990 Nov 20;29(46):10461-5. PMID:2271657

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