6lb6

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==Crystal structure of dimeric RXR-LBD complexed with partial agonist NEt-4IB and TIF2 co-activator==
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<StructureSection load='6lb6' size='340' side='right'caption='[[6lb6]]' scene=''>
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<StructureSection load='6lb6' size='340' side='right'caption='[[6lb6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6lb6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LB6 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lb6 OCA], [http://pdbe.org/6lb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lb6 RCSB], [http://www.ebi.ac.uk/pdbsum/6lb6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lb6 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E8O:6-[ethyl-[4-(2-methylpropoxy)-3-propan-2-yl-phenyl]amino]pyridine-3-carboxylic+acid'>E8O</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lb6 OCA], [https://pdbe.org/6lb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lb6 RCSB], [https://www.ebi.ac.uk/pdbsum/6lb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lb6 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
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== Function ==
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[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Imai D]]
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[[Category: Ito N]]
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[[Category: Kakuta H]]
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[[Category: Nakano S]]
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[[Category: Numoto N]]

Revision as of 10:54, 22 November 2023

Crystal structure of dimeric RXR-LBD complexed with partial agonist NEt-4IB and TIF2 co-activator

PDB ID 6lb6

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