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1gwx

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Current revision (23:33, 27 December 2023) (edit) (undo)
 
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<StructureSection load='1gwx' size='340' side='right'caption='[[1gwx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1gwx' size='340' side='right'caption='[[1gwx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1gwx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1GWX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1gwx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GWX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=433:2-(4-{3-[1-[2-(2-CHLORO-6-FLUORO-PHENYL)-ETHYL]-3-(2,3-DICHLORO-PHENYL)-UREIDO]-PROPYL}-PHENOXY)-2-METHYL-PROPIONIC+ACID'>433</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPARD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=433:2-(4-{3-[1-[2-(2-CHLORO-6-FLUORO-PHENYL)-ETHYL]-3-(2,3-DICHLORO-PHENYL)-UREIDO]-PROPYL}-PHENOXY)-2-METHYL-PROPIONIC+ACID'>433</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1gwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwx OCA], [http://pdbe.org/1gwx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gwx RCSB], [http://www.ebi.ac.uk/pdbsum/1gwx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwx OCA], [https://pdbe.org/1gwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gwx RCSB], [https://www.ebi.ac.uk/pdbsum/1gwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN]] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>
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[https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Blanchard, S]]
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[[Category: Blanchard S]]
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[[Category: Brown, P]]
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[[Category: Brown P]]
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[[Category: Bruce, G W]]
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[[Category: Bruce GW]]
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[[Category: Kliewer, S A]]
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[[Category: Kliewer SA]]
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[[Category: Lambert, M H]]
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[[Category: Lambert MH]]
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[[Category: Lehmann, J]]
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[[Category: Lehmann J]]
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[[Category: Milburn, M V]]
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[[Category: Milburn MV]]
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[[Category: Montana, V G]]
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[[Category: Montana VG]]
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[[Category: Park, D J]]
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[[Category: Park DJ]]
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[[Category: Sternbach, D]]
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[[Category: Sternbach D]]
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[[Category: Willson, T M]]
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[[Category: Willson TM]]
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[[Category: Xu, H E]]
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[[Category: Xu HE]]
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[[Category: Fatty acid]]
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[[Category: Nuclear receptor fold]]
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[[Category: Ppar]]
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[[Category: Transcription]]
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Current revision

MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS

PDB ID 1gwx

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OCA

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