1d3s

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{{STRUCTURE_1d3s| PDB=1d3s | SCENE= }}
{{STRUCTURE_1d3s| PDB=1d3s | SCENE= }}
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'''1.4 A crystal structure of nitrophorin 4 from Rhodnius prolixis at pH=5.6.'''
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===1.4 A crystal structure of nitrophorin 4 from Rhodnius prolixis at pH=5.6.===
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==Overview==
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The nitrophorins comprise an unusual family of proteins that use ferric (Fe(III)) heme to transport highly reactive nitric oxide (NO) from the salivary gland of a blood sucking bug to the victim, resulting in vasodilation and reduced blood coagulation. We have determined structures of nitrophorin 4 in complexes with H2O, cyanide and nitric oxide. These structures reveal a remarkable feature: the nitrophorins have a broadly open distal pocket in the absence of NO, but upon NO binding, three or more water molecules are expelled and two loops fold into the distal pocket, resulting in the packing of hydrophobic groups around the NO molecule and increased distortion of the heme. In this way, the protein apparently forms a 'hydrophobic trap' for the NO molecule. The structures are very accurate, ranging between 1.6 and 1.4 A resolutions.
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(as it appears on PubMed at http://www.pubmed.gov), where 10876239 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10876239}}
==About this Structure==
==About this Structure==
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[[Category: Nitric oxide transport]]
[[Category: Nitric oxide transport]]
[[Category: Vasodilator]]
[[Category: Vasodilator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:25:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:20:29 2008''

Revision as of 19:20, 30 June 2008

Image:1d3s.png

Template:STRUCTURE 1d3s

1.4 A crystal structure of nitrophorin 4 from Rhodnius prolixis at pH=5.6.

Template:ABSTRACT PUBMED 10876239

About this Structure

1D3S is a Single protein structure of sequence from Rhodnius prolixus. Full crystallographic information is available from OCA.

Reference

Nitric oxide binding to nitrophorin 4 induces complete distal pocket burial., Weichsel A, Andersen JF, Roberts SA, Montfort WR, Nat Struct Biol. 2000 Jul;7(7):551-4. PMID:10876239

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