Tetracycline repressor protein
From Proteopedia
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<StructureSection load='2trt' size='350' side='right' scene='47/477771/Cv/1' caption='Tetracycline repressor protein complex with tetracycline and Mg+2 ion (green), [[2trt]]'> | <StructureSection load='2trt' size='350' side='right' scene='47/477771/Cv/1' caption='Tetracycline repressor protein complex with tetracycline and Mg+2 ion (green), [[2trt]]'> | ||
== Function == | == Function == | ||
| - | '''Tetracycline repressor protein''' (TetR) causes the resistance of bacterial cells to antibiotics like tetracycline (TC). TetR binds TC with higher affinity than the ribosome thus preventing TC from binding there and inhibiting the pathogenic bacteria protein synthesis<ref>PMID:21261817</ref>. '''HTH-type TetR''' is a prokaryotic TetR which contains a DNA-binding '''H'''elix-'''T'''urn-'''H'''elix domain of ca. 60 residues. | + | '''Tetracycline repressor protein''' (TetR) causes the resistance of bacterial cells to antibiotics like tetracycline (TC). TetR binds TC with higher affinity than the ribosome thus preventing TC from binding there and inhibiting the pathogenic bacteria protein synthesis<ref>PMID:21261817</ref>. '''HTH-type TetR''' is a prokaryotic TetR which contains a DNA-binding '''H'''elix-'''T'''urn-'''H'''elix domain of ca. 60 residues<ref>PMID:8869638</ref>. |
== Structural highlights == | == Structural highlights == | ||
Current revision
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References
- ↑ Bertram R, Hillen W. The application of Tet repressor in prokaryotic gene regulation and expression. Microb Biotechnol. 2008 Jan;1(1):2-16. doi: 10.1111/j.1751-7915.2007.00001.x. PMID:21261817 doi:http://dx.doi.org/10.1111/j.1751-7915.2007.00001.x
- ↑ Aramaki H, Yagi N, Suzuki M. Residues important for the function of a multihelical DNA binding domain in the new transcription factor family of Cam and Tet repressors. Protein Eng. 1995 Dec;8(12):1259-66. doi: 10.1093/protein/8.12.1259. PMID:8869638 doi:http://dx.doi.org/10.1093/protein/8.12.1259
- ↑ Hinrichs W, Kisker C, Duvel M, Muller A, Tovar K, Hillen W, Saenger W. Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance. Science. 1994 Apr 15;264(5157):418-20. PMID:8153629
