This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Mycobacterium Tuberculosis Transpeptidase Domain
From Proteopedia
| Line 8: | Line 8: | ||
When the ß-lactams bind to the PBPs, it induces the degradation of the cell wall by inhibits the activity of transpeptidase. | When the ß-lactams bind to the PBPs, it induces the degradation of the cell wall by inhibits the activity of transpeptidase. | ||
== Disease == | == Disease == | ||
| - | + | TB is a human pulmonary disease which | |
== Relevance == | == Relevance == | ||
| Line 18: | Line 18: | ||
== References == | == References == | ||
Filippova, E. V., Kieser, K. J., Luan, C. H., Wawrzak, Z., Kiryukhina, O., Rubin, E. J., & Anderson, W. F. (2016). Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin‐binding protein PonA1 reveal potential mechanisms of antibiotic resistance. The FEBS journal, 283(12), 2206-2218. | Filippova, E. V., Kieser, K. J., Luan, C. H., Wawrzak, Z., Kiryukhina, O., Rubin, E. J., & Anderson, W. F. (2016). Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin‐binding protein PonA1 reveal potential mechanisms of antibiotic resistance. The FEBS journal, 283(12), 2206-2218. | ||
| + | Maria-Magdalena Patru, Martin S. Pavelka, Jr. A Role for the Class A Penicillin-Binding Protein PonA2 in the Survival of Mycobacterium smegmatis under Conditions of Nonreplication, J Bacteriol. 2010 Jun; 192(12): 3043–3054. Published online 2010 Apr 16. doi: 10.1128/JB.00025-10 | ||
Revision as of 16:53, 24 November 2020
Mtb Transpeptidase Domain in Complex with Penicillin
| |||||||||||
References
Filippova, E. V., Kieser, K. J., Luan, C. H., Wawrzak, Z., Kiryukhina, O., Rubin, E. J., & Anderson, W. F. (2016). Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin‐binding protein PonA1 reveal potential mechanisms of antibiotic resistance. The FEBS journal, 283(12), 2206-2218. Maria-Magdalena Patru, Martin S. Pavelka, Jr. A Role for the Class A Penicillin-Binding Protein PonA2 in the Survival of Mycobacterium smegmatis under Conditions of Nonreplication, J Bacteriol. 2010 Jun; 192(12): 3043–3054. Published online 2010 Apr 16. doi: 10.1128/JB.00025-10
