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6tpm
From Proteopedia
(Difference between revisions)
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==Crystal structure of AmpC from E.coli with Relebactam (MK-7655)== | ==Crystal structure of AmpC from E.coli with Relebactam (MK-7655)== | ||
| - | <StructureSection load='6tpm' size='340' side='right'caption='[[6tpm]]' scene=''> | + | <StructureSection load='6tpm' size='340' side='right'caption='[[6tpm]], [[Resolution|resolution]] 1.72Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TPM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TPM FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6tpm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TPM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TPM FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tpm OCA], [http://pdbe.org/6tpm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tpm RCSB], [http://www.ebi.ac.uk/pdbsum/6tpm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tpm ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MK7:(2S,5R)-1-FORMYL-N-(PIPERIDIN-4-YL)-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>MK7</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ampC, ampA, b4150, JW4111 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tpm OCA], [http://pdbe.org/6tpm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tpm RCSB], [http://www.ebi.ac.uk/pdbsum/6tpm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tpm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI]] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Beta-lactamase]] | ||
| + | [[Category: Ecoli]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Brem J]] | + | [[Category: Brem, J]] |
| - | [[Category: Lang | + | [[Category: Lang, P A]] |
| - | [[Category: Leissing | + | [[Category: Leissing, T M]] |
| - | [[Category: Schofield | + | [[Category: Schofield, C J]] |
| + | [[Category: Antibiotic resistance]] | ||
| + | [[Category: Beta lactamase]] | ||
| + | [[Category: Dbo]] | ||
| + | [[Category: Diazabicyclooctane]] | ||
| + | [[Category: Hydrolase]] | ||
Revision as of 08:09, 2 December 2020
Crystal structure of AmpC from E.coli with Relebactam (MK-7655)
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