6wzm

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====
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==LY3041658 Fab bound to CXCL8==
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<StructureSection load='6wzm' size='340' side='right'caption='[[6wzm]]' scene=''>
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<StructureSection load='6wzm' size='340' side='right'caption='[[6wzm]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6wzm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WZM FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wzm OCA], [http://pdbe.org/6wzm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wzm RCSB], [http://www.ebi.ac.uk/pdbsum/6wzm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wzm ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wzm OCA], [https://pdbe.org/6wzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wzm RCSB], [https://www.ebi.ac.uk/pdbsum/6wzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wzm ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL8_HUMAN IL8_HUMAN] IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.<ref>PMID:2145175</ref> <ref>PMID:2212672</ref> <ref>PMID:11978786</ref>
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==See Also==
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Druzina Z]]
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[[Category: Durbin JD]]

Revision as of 07:10, 3 April 2024

LY3041658 Fab bound to CXCL8

PDB ID 6wzm

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