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| | <StructureSection load='1jl5' size='340' side='right'caption='[[1jl5]], [[Resolution|resolution]] 2.10Å' scene=''> | | <StructureSection load='1jl5' size='340' side='right'caption='[[1jl5]], [[Resolution|resolution]] 2.10Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1jl5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1JL5 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1jl5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JL5 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1g9u|1g9u]]</div></td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YopM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jl5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jl5 OCA], [https://pdbe.org/1jl5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jl5 RCSB], [https://www.ebi.ac.uk/pdbsum/1jl5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jl5 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1jl5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jl5 OCA], [http://pdbe.org/1jl5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jl5 RCSB], [http://www.ebi.ac.uk/pdbsum/1jl5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jl5 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/YOPM_YERPE YOPM_YERPE]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues (By similarity). | + | [https://www.uniprot.org/uniprot/YOPM_YERPE YOPM_YERPE] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues (By similarity). |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Anderson, D E]] | + | [[Category: Yersinia pestis]] |
| - | [[Category: Evdokimov, A G]] | + | [[Category: Anderson DE]] |
| - | [[Category: Routzahn, K M]] | + | [[Category: Evdokimov AG]] |
| - | [[Category: Waugh, D S]] | + | [[Category: Routzahn KM]] |
| - | [[Category: Effector protein]] | + | [[Category: Waugh DS]] |
| - | [[Category: Leucine-rich repeat]]
| + | |
| - | [[Category: Molecular pathogenesis]]
| + | |
| - | [[Category: Toxin]]
| + | |
| - | [[Category: Virulence factor]]
| + | |
| Structural highlights
Function
YOPM_YERPE Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues (By similarity).
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Many Gram-negative bacterial pathogens employ a contact-dependent (type III) secretion system to deliver effector proteins into the cytosol of animal or plant cells. Collectively, these effectors enable the bacteria to evade the immune response of the infected organism by modulating host-cell functions. YopM, a member of the leucine-rich repeat protein superfamily, is an effector produced by the bubonic plague bacterium, Yersinia pestis, that is essential for virulence. Here, we report crystal structures of YopM at 2.4 and 2.1 A resolution. Among all leucine-rich repeat family members whose atomic coordinates have been reported, the repeating unit of YopM has the least canonical secondary structure. In both crystals, four YopM monomers form a hollow cylinder with an inner diameter of 35 A. The domain that targets YopM for translocation into eukaryotic cells adopts a well-ordered, alpha-helical conformation that packs tightly against the proximal leucine-rich repeat module. A similar alpha-helical domain can be identified in virulence-associated leucine-rich repeat proteins produced by Salmonella typhimurium and Shigella flexneri, and in the conceptual translation products of several open reading frames in Y. pestis.
Unusual molecular architecture of the Yersinia pestis cytotoxin YopM: a leucine-rich repeat protein with the shortest repeating unit.,Evdokimov AG, Anderson DE, Routzahn KM, Waugh DS J Mol Biol. 2001 Sep 28;312(4):807-21. PMID:11575934[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Evdokimov AG, Anderson DE, Routzahn KM, Waugh DS. Unusual molecular architecture of the Yersinia pestis cytotoxin YopM: a leucine-rich repeat protein with the shortest repeating unit. J Mol Biol. 2001 Sep 28;312(4):807-21. PMID:11575934 doi:10.1006/jmbi.2001.4973
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