1k9u

<table><tr><td colspan='2'>[[1k9u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Common_timothy Common timothy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K9U OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1K9U FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Phlpr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=15957 Common timothy])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1k9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k9u OCA], [http://pdbe.org/1k9u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k9u RCSB], [http://www.ebi.ac.uk/pdbsum/1k9u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1k9u ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

The timothy grass pollen allergen Phl p 7 assembles most of the IgE epitopes of a novel family of 2 EF-hand calcium-binding proteins and therefore represents a diagnostic marker allergen and vaccine candidate for immunotherapy. Here we report the first three-dimensional structure of a representative of the 2 EF-hand allergen family, Phl p 7, in the calcium-bound form. The protein occurs as a novel dimer assembly with unique features: in contrast to well known EF-hand proteins such as calmodulin, parvalbumin or the S100 proteins, Phl p 7 adopts an extended conformation. Two protein monomers assemble in a head-to-tail arrangement with domain-swapped EF-hand pairing. The intertwined dimer adopts a barrel-like structure with an extended hydrophobic cavity providing a ligand-binding site. Calcium binding acts as a conformational switch between an open and a closed dimeric form of Phl p 7. These findings are interesting in the context of lipid- and calcium-dependent pollen tube growth. Furthermore, the structure of Phl p 7 allows for the rational development of vaccine strategies for treatment of sensitized allergic patients.

The cross-reactive calcium-binding pollen allergen, Phl p 7, reveals a novel dimer assembly.,Verdino P, Westritschnig K, Valenta R, Keller W EMBO J. 2002 Oct 1;21(19):5007-16. PMID:12356717<ref>PMID:12356717</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Common timothy]]

[[Category: Keller, W]]

[[Category: Valenta, R]]

[[Category: Verdino, P]]

[[Category: Westritschnig, K]]

[[Category: Pollen allergen]]