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1knw

From Proteopedia

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Current revision (08:02, 3 April 2024) (edit) (undo)
 
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<StructureSection load='1knw' size='340' side='right'caption='[[1knw]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='1knw' size='340' side='right'caption='[[1knw]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1knw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KNW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1KNW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1knw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KNW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KNW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ko0|1ko0]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LysA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1knw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1knw OCA], [https://pdbe.org/1knw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1knw RCSB], [https://www.ebi.ac.uk/pdbsum/1knw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1knw ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diaminopimelate_decarboxylase Diaminopimelate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.20 4.1.1.20] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1knw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1knw OCA], [http://pdbe.org/1knw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1knw RCSB], [http://www.ebi.ac.uk/pdbsum/1knw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1knw ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DCDA_ECOLI DCDA_ECOLI]] Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. Is not active against the DD- or LL-isomers of diaminopimelate.<ref>PMID:14343156</ref> <ref>PMID:11856852</ref> <ref>PMID:18508763</ref>
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[https://www.uniprot.org/uniprot/DCDA_ECOLI DCDA_ECOLI] Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. Is not active against the DD- or LL-isomers of diaminopimelate.<ref>PMID:14343156</ref> <ref>PMID:11856852</ref> <ref>PMID:18508763</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Diaminopimelate decarboxylase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Blagova, L]]
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[[Category: Blagova L]]
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[[Category: Bose, N]]
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[[Category: Bose N]]
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[[Category: Levdikov, V]]
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[[Category: Levdikov V]]
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[[Category: Momany, C]]
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[[Category: Momany C]]
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[[Category: Decarboxylation]]
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[[Category: Diaminopimelate]]
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[[Category: Lyase]]
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[[Category: Lysine]]
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[[Category: Pyridoxal-phosphate]]
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[[Category: Tim-barrel]]
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Current revision

Crystal structure of diaminopimelate decarboxylase

PDB ID 1knw

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