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| | <StructureSection load='1ky2' size='340' side='right'caption='[[1ky2]], [[Resolution|resolution]] 1.60Å' scene=''> | | <StructureSection load='1ky2' size='340' side='right'caption='[[1ky2]], [[Resolution|resolution]] 1.60Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1ky2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KY2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1KY2 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1ky2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KY2 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ek0|1ek0]], [[1ky3|1ky3]]</div></td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YPT7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ky2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ky2 OCA], [https://pdbe.org/1ky2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ky2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ky2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ky2 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1ky2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ky2 OCA], [http://pdbe.org/1ky2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ky2 RCSB], [http://www.ebi.ac.uk/pdbsum/1ky2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ky2 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/YPT7_YEAST YPT7_YEAST]] Needed for homotypic vacuole fusion, the last step in the vacuole inheritance process. | + | [https://www.uniprot.org/uniprot/YPT7_YEAST YPT7_YEAST] Needed for homotypic vacuole fusion, the last step in the vacuole inheritance process. |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Atcc 18824]] | |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Constantinescu, A T]] | + | [[Category: Saccharomyces cerevisiae]] |
| - | [[Category: Rak, A]] | + | [[Category: Constantinescu A-T]] |
| - | [[Category: Scheidig, A J]] | + | [[Category: Rak A]] |
| - | [[Category: Endocytosis]] | + | [[Category: Scheidig AJ]] |
| - | [[Category: Endocytosis-exocytosis complex]]
| + | |
| - | [[Category: G protein]]
| + | |
| - | [[Category: Gtp hydrolysis]]
| + | |
| - | [[Category: Hydrolase]]
| + | |
| - | [[Category: Vesicular traffic]]
| + | |
| - | [[Category: Ypt/rab protein]]
| + | |
| Structural highlights
Function
YPT7_YEAST Needed for homotypic vacuole fusion, the last step in the vacuole inheritance process.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The GTPase Ypt7p from S. cerevisiae is involved in late endosome-to-vacuole transport and homotypic vacuole fusion. We present crystal structures of the GDP- and GppNHp-bound conformation of Ypt7p solved at 1.35 and 1.6 A resolution, respectively. Despite the similarity of the overall structure to other Ypt/Rab proteins, Ypt7p displays small but significant differences. The Ypt7p-specific residues Tyr33 and Tyr37 cause a difference in the main chain trace of the RabSF2 region and form a characteristic surface epitope. Ypt7p*GppNHp does not display the helix alpha2, characteristic of the Ras-superfamily, but instead possess an extended loop L4/L5. Due to insertions in loops L3 and L7, the neighboring RabSF1 and RabSF4 regions are different in their conformations to those of other Ypt/Rab proteins.
Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases.,Constantinescu AT, Rak A, Alexandrov K, Esters H, Goody RS, Scheidig AJ Structure. 2002 Apr;10(4):569-79. PMID:11937061[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Constantinescu AT, Rak A, Alexandrov K, Esters H, Goody RS, Scheidig AJ. Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases. Structure. 2002 Apr;10(4):569-79. PMID:11937061
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