Thymidine kinase
From Proteopedia
(Difference between revisions)
| Line 26: | Line 26: | ||
*Thymidine kinase complex with reactants or products | *Thymidine kinase complex with reactants or products | ||
| + | **[[2vp9]], [[2vp4]] – DmTK + CMP analog – ''Drosophila melanogaster''<br /> | ||
| + | **[[2vp2]] – DmTK + GTP analog <br /> | ||
| + | **[[2vp6]] – DmTK + UMP analog <br /> | ||
| + | **[[1ot3]] – DmTK + THM <br /> | ||
| + | **[[2vqs]], [[2jj8]], [[2vp5]] - DmTK + nycleotide analog<br /> | ||
| + | **[[1j90]], [[1zmx]] - DmTK (mutant) + nycleotide analog<br /> | ||
| + | **[[2vpp]] – DmTK + cancer drug<br /> | ||
**[[1e2i]] - HsvTK + hydroxypropyladenine<BR /> | **[[1e2i]] - HsvTK + hydroxypropyladenine<BR /> | ||
**[[1e2j]] - HsvTK (mutant) + THM<BR /> | **[[1e2j]] - HsvTK (mutant) + THM<BR /> | ||
| Line 52: | Line 59: | ||
*Thymidine kinase complex with feed-back inhibitor | *Thymidine kinase complex with feed-back inhibitor | ||
| + | **[[1oe0]], [[2vp0]], [[2jcs]] – DmTK + dTTP <br /> | ||
| + | **[[1zm7]] – DmTK (mutant) + dTTP <br /> | ||
**[[2j87]] – TK + TTP – Vaccinia virus<BR /> | **[[2j87]] – TK + TTP – Vaccinia virus<BR /> | ||
**[[2uz3]] – TK (mutant) + TTP – ''Ureaplasma urealyticum''<BR /> | **[[2uz3]] – TK (mutant) + TTP – ''Ureaplasma urealyticum''<BR /> | ||
Revision as of 08:08, 30 November 2020
| |||||||||||
3D Structures of thymidine kinase
Updated on 30-November-2020
References
- ↑ Perez-Perez MJ, Priego EM, Hernandez AI, Familiar O, Camarasa MJ, Negri A, Gago F, Balzarini J. Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): present and future. Med Res Rev. 2008 Sep;28(5):797-820. doi: 10.1002/med.20124. PMID:18459168 doi:http://dx.doi.org/10.1002/med.20124
- ↑ He Q, Zhang P, Zou L, Li H, Wang X, Zhou S, Fornander T, Skog S. Concentration of thymidine kinase 1 in serum (S-TK1) is a more sensitive proliferation marker in human solid tumors than its activity. Oncol Rep. 2005 Oct;14(4):1013-9. PMID:16142366
- ↑ Saada A, Shaag A, Mandel H, Nevo Y, Eriksson S, Elpeleg O. Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy. Nat Genet. 2001 Nov;29(3):342-4. PMID:11687801 doi:http://dx.doi.org/10.1038/ng751
- ↑ Kosinska U, Carnrot C, Sandrini MP, Clausen AR, Wang L, Piskur J, Eriksson S, Eklund H. Structural studies of thymidine kinases from Bacillus anthracis and Bacillus cereus provide insights into quaternary structure and conformational changes upon substrate binding. FEBS J. 2007 Feb;274(3):727-37. PMID:17288553 doi:10.1111/j.1742-4658.2006.05617.x
