1d6a

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[[Image:1d6a.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1d6a| PDB=1d6a | SCENE= }}
{{STRUCTURE_1d6a| PDB=1d6a | SCENE= }}
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'''STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN COMPLEXED WITH GUANINE'''
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===STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN COMPLEXED WITH GUANINE===
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==Overview==
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Pokeweed antiviral protein (PAP) is a ribosome-inactivating protein (RIP), which enzymatically removes a single adenine base from a conserved, surface exposed loop sequence of ribosomal rRNA. We now present unprecedented experimental evidence that PAP can release not only adenine but guanine as well from Escherichia coli rRNA, albeit at a rate 20 times slower than for adenine. We also report X-ray structure analysis and supporting modeling studies for the interactions of PAP with guanine. Our modeling studies indicated that PAP can accommodate a guanine base in the active site pocket without large conformational changes. This prediction was experimentally confirmed, since a guanine base was visible in the active site pocket of the crystal structure of the PAP-guanine complex.
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The line below this paragraph, {{ABSTRACT_PUBMED_10595542}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10595542 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10595542}}
==About this Structure==
==About this Structure==
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[[Category: Pokeweed antiviral protein]]
[[Category: Pokeweed antiviral protein]]
[[Category: Ribosome inactivating protein]]
[[Category: Ribosome inactivating protein]]
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Revision as of 19:31, 30 June 2008

Image:1d6a.png

Template:STRUCTURE 1d6a

STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN COMPLEXED WITH GUANINE

Template:ABSTRACT PUBMED 10595542

About this Structure

1D6A is a Single protein structure of sequence from Phytolacca americana. Full crystallographic information is available from OCA.

Reference

X-ray crystallographic analysis of the structural basis for the interaction of pokeweed antiviral protein with guanine residues of ribosomal RNA., Kurinov IV, Rajamohan F, Venkatachalam TK, Uckun FM, Protein Sci. 1999 Nov;8(11):2399-405. PMID:10595542

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