1d6k

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[[Image:1d6k.gif|left|200px]]
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{{STRUCTURE_1d6k| PDB=1d6k | SCENE= }}
{{STRUCTURE_1d6k| PDB=1d6k | SCENE= }}
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'''NMR SOLUTION STRUCTURE OF THE 5S RRNA E-LOOP/L25 COMPLEX'''
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===NMR SOLUTION STRUCTURE OF THE 5S RRNA E-LOOP/L25 COMPLEX===
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==Overview==
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The structure of the complex between ribosomal protein L25 and a 37 nucleotide RNA molecule, which contains the E-loop and helix IV regions of the E-domain of Escherichia coli 5S rRNA, has been determined to an overall r.m.s. displacement of 1.08 A (backbone heavy atoms) by heteronuclear NMR spectroscopy (Protein Databank code 1d6k). The interacting molecular surfaces are bipartite for both the RNA and the protein. One side of the six-stranded beta-barrel of L25 recognizes the minor groove of the E-loop with very little change in the conformations of either the protein or the RNA and with the RNA-protein interactions occurring mainly along one strand of the E-loop duplex. This minor groove recognition module includes two parallel beta-strands of L25, a hitherto unknown RNA binding topology. Binding of the RNA also induces conversion of a flexible loop to an alpha-helix in L25, the N-terminal tip of which interacts with the widened major groove at the E-loop/helix IV junction of the RNA. The structure of the complex reveals that the E-domain RNA serves as a preformed docking partner, while the L25 protein has one preformed and one induced recognition module.
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(as it appears on PubMed at http://www.pubmed.gov), where 10562563 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10562563}}
==About this Structure==
==About this Structure==
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1D6K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D6K OCA].
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1D6K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D6K OCA].
==Reference==
==Reference==
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[[Category: Wohnert, J.]]
[[Category: Wohnert, J.]]
[[Category: Protein-rna complex]]
[[Category: Protein-rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:30:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:32:26 2008''

Revision as of 19:32, 30 June 2008

Image:1d6k.png

Template:STRUCTURE 1d6k

NMR SOLUTION STRUCTURE OF THE 5S RRNA E-LOOP/L25 COMPLEX

Template:ABSTRACT PUBMED 10562563

About this Structure

1D6K is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

The NMR structure of the 5S rRNA E-domain-protein L25 complex shows preformed and induced recognition., Stoldt M, Wohnert J, Ohlenschlager O, Gorlach M, Brown LR, EMBO J. 1999 Nov 15;18(22):6508-21. PMID:10562563

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