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6x8q

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Current revision (07:10, 3 April 2024) (edit) (undo)
 
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====
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==Crystal structure of 3D11 Fab in complex with Plasmodium berghei circumsporozoite protein PAPP peptide==
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<StructureSection load='6x8q' size='340' side='right'caption='[[6x8q]]' scene=''>
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<StructureSection load='6x8q' size='340' side='right'caption='[[6x8q]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6x8q]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Plasmodium_berghei_ANKA Plasmodium berghei ANKA]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X8Q FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x8q OCA], [http://pdbe.org/6x8q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6x8q RCSB], [http://www.ebi.ac.uk/pdbsum/6x8q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6x8q ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x8q OCA], [https://pdbe.org/6x8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x8q RCSB], [https://www.ebi.ac.uk/pdbsum/6x8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x8q ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CSP_PLABA CSP_PLABA] Essential sporozoite protein (PubMed:6985745, PubMed:15630135, PubMed:16207248, PubMed:18005753, PubMed:21262960). In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands (PubMed:16207248, PubMed:21262960). In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes (PubMed:6985745, PubMed:15630135, PubMed:18005753, PubMed:21262960). Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes (PubMed:18005753).<ref>PMID:15630135</ref> <ref>PMID:16207248</ref> <ref>PMID:18005753</ref> <ref>PMID:21262960</ref> <ref>PMID:6985745</ref> In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.<ref>PMID:18005753</ref> <ref>PMID:21262960</ref>
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==See Also==
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Mus musculus]]
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[[Category: Plasmodium berghei ANKA]]
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[[Category: Julien JP]]
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[[Category: Thai E]]

Current revision

Crystal structure of 3D11 Fab in complex with Plasmodium berghei circumsporozoite protein PAPP peptide

PDB ID 6x8q

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