7aol

<StructureSection load='7aol' size='340' side='right'caption='[[7aol]], [[Resolution|resolution]] 1.47&Aring;' scene=''>

<table><tr><td colspan='2'>[[7aol]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/2019-ncov 2019-ncov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AOL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7AOL FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=RQH:(1~{S})-1-(4-chloranylphenoxy)-1-imidazol-1-yl-3,3-dimethyl-butan-2-one'>RQH</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7aol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aol OCA], [http://pdbe.org/7aol PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7aol RCSB], [http://www.ebi.ac.uk/pdbsum/7aol PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7aol ProSAT]</span></td></tr>

== Function ==

[[http://www.uniprot.org/uniprot/A0A6M4NAY4_SARS2 A0A6M4NAY4_SARS2]] Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.[ARBA:ARBA00002182] Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.[ARBA:ARBA00003443] May participate in viral replication by acting as a ssRNA-binding protein.[ARBA:ARBA00002012] May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.[ARBA:ARBA00003115] Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system.[ARBA:ARBA00002840] Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.[ARBA:ARBA00002798] Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.[ARBA:ARBA00002960] Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.[ARBA:ARBA00002697] Responsible for replication and transcription of the viral RNA genome.[ARBA:ARBA00003927]

[[Category: 2019-ncov]]

[[Category: Awel, S]]

[[Category: Beck, T]]

[[Category: Betzel, C]]

[[Category: Brehm, W]]

[[Category: Brognaro, H]]

[[Category: Chapman, H N]]

[[Category: Chari, A]]

[[Category: Domaracky, M]]

[[Category: Doyle, J J]]

[[Category: Dunkel, I]]

[[Category: Ehrt, C]]

[[Category: Ellinger, B]]

[[Category: Esperanza, G Pena]]

[[Category: Falke, S]]

[[Category: Feiler, C]]

[[Category: Fischer, P]]

[[Category: Fleckenstein, H]]

[[Category: Franca, B Alves]]

[[Category: Galchenkova, M]]

[[Category: Garcia, Y Fernandez]]

[[Category: Gelisio, L]]

[[Category: Gevorkov, Y]]

[[Category: Ginn, H]]

[[Category: Giseler, H]]

[[Category: Gribbon, P]]

[[Category: Groessler, M]]

[[Category: Guenther, S]]

[[Category: Hakanpaeae, J]]

[[Category: Han, H]]

[[Category: Hennicke, V]]

[[Category: Hilgenfeld, R]]

[[Category: Knoska, J]]

[[Category: Koua, F]]

[[Category: Kuzikov, M]]

[[Category: Lane, T J]]

[[Category: Li, C]]

[[Category: Lieske, J]]

[[Category: Lorenzen, K]]

[[Category: Mashour, A Rahmani]]

[[Category: Meents, A]]

[[Category: Mehrabi, P]]

[[Category: Meier, S]]

[[Category: Melo, D]]

[[Category: Meyer, J]]

[[Category: Noei, H]]

[[Category: Norton-Baker, B]]

[[Category: Oberthuer, D]]

[[Category: Paulraj, L X]]

[[Category: Pearson, A]]

[[Category: Peck, A]]

[[Category: Perbandt, M]]

[[Category: Pletzer-Zelgert, J]]

[[Category: Rarey, M]]

[[Category: Reinke, P]]

[[Category: Saouane, S]]

[[Category: Schmidt, C]]

[[Category: Schubert, R]]

[[Category: Schulz, E C]]

[[Category: Schwinzer, M]]

[[Category: Seychell, B]]

[[Category: Tidow, H]]

[[Category: Tolstikova, A]]

[[Category: Trost, F]]

[[Category: Turk, D]]

[[Category: Ullah, N]]

[[Category: Weiss, M]]

[[Category: Werner, N]]

[[Category: White, T A]]

[[Category: Wolf, M]]

[[Category: Wollenhaupt, J]]

[[Category: Yefanov, O]]

[[Category: Zaliani, A]]

[[Category: Zhang, L]]

[[Category: Sars-cov-2]]