7dh6
From Proteopedia
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==Crystal structure of PLRG1== | ==Crystal structure of PLRG1== | ||
| - | <StructureSection load='7dh6' size='340' side='right'caption='[[7dh6]]' scene=''> | + | <StructureSection load='7dh6' size='340' side='right'caption='[[7dh6]], [[Resolution|resolution]] 2.58Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DH6 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[7dh6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DH6 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLRG1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dh6 OCA], [https://pdbe.org/7dh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dh6 RCSB], [https://www.ebi.ac.uk/pdbsum/7dh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dh6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/PLRG1_HUMAN PLRG1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | PLRG1 is a evolutionarily conserved protein in spliceosome and plays an important role in maintaining the integral part of the splicoeosme and its proper splicing. Here we solved the high resolution crystal structure of the WD40 domain of human PLRG1 by crystallography and compared our crystal structure with the cryo-EM structure of PLRG1 bound with other splicing factors. We found that two loops of the WD40 domain become resolved upon binding to the proteins within the spliceosome. Thus our work characterize the dynamic property of PLRG1 during the spliceosome assembly by presenting its apo structure. | ||
| + | |||
| + | Crystal structure of the WD40 domain of human PLRG1.,Wang X, Li Y, Dai H, Xu C Biochem Biophys Res Commun. 2021 Jan 1;534:474-477. doi:, 10.1016/j.bbrc.2020.11.057. Epub 2020 Nov 22. PMID:33239170<ref>PMID:33239170</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7dh6" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Wang X]] | + | [[Category: Wang, X]] |
| - | [[Category: Xu C]] | + | [[Category: Xu, C]] |
| + | [[Category: Plrg1 offers an interesting link between the control of pre-mrna splicing and dna metabolism]] | ||
| + | [[Category: Splicing]] | ||
Revision as of 14:57, 17 June 2021
Crystal structure of PLRG1
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