1d7h

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[[Image:1d7h.gif|left|200px]]
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{{Seed}}
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[[Image:1d7h.png|left|200px]]
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{{STRUCTURE_1d7h| PDB=1d7h | SCENE= }}
{{STRUCTURE_1d7h| PDB=1d7h | SCENE= }}
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'''FKBP COMPLEXED WITH DMSO'''
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===FKBP COMPLEXED WITH DMSO===
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==Overview==
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A new crystal form of native FK506 binding protein (FKBP) has been obtained which has proved useful in ligand binding studies. Three different small molecule ligand complexes and the native enzyme have been determined at higher resolution than 2.0 A. Dissociation constants of the related small molecule ligands vary from 20 mM for dimethylsulphoxide to 200 microM for tetrahydrothiophene 1-oxide. Comparison of the four available crystal structures shows that the protein structures are identical to within experimental error, but there are differences in the water structure in the active site. Analysis of the calculated buried surface areas of these related ligands provides an estimated van der Waals contribution to the binding energy of -0.5 kJ/A(2) for non-polar interactions between ligand and protein.
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The line below this paragraph, {{ABSTRACT_PUBMED_10656803}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10656803 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10656803}}
==About this Structure==
==About this Structure==
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[[Category: Immunophilin]]
[[Category: Immunophilin]]
[[Category: Isomerase]]
[[Category: Isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:31:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:37:20 2008''

Revision as of 19:37, 30 June 2008

Image:1d7h.png

Template:STRUCTURE 1d7h

FKBP COMPLEXED WITH DMSO

Template:ABSTRACT PUBMED 10656803

About this Structure

1D7H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies., Burkhard P, Taylor P, Walkinshaw MD, J Mol Biol. 2000 Jan 28;295(4):953-62. PMID:10656803

Page seeded by OCA on Mon Jun 30 22:37:20 2008

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