1msp

<table><tr><td colspan='2'>[[1msp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ascsu Ascsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1MSP FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALPHA MSP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6253 ASCSU])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1msp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1msp OCA], [http://pdbe.org/1msp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1msp RCSB], [http://www.ebi.ac.uk/pdbsum/1msp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1msp ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/MSP1_ASCSU MSP1_ASCSU]] Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

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== Publication Abstract from PubMed ==

We have determined the structure of the Ascaris major sperm protein (MSP) to 2.5 A resolution using X-ray crystallography. The MSP polypeptide chain has an immunoglobulin-like fold based on a seven-stranded beta sandwich. In two strands, cis-proline residues impart distinctive kinks, and overall the structure most closely resembles that of the N-terminal domain of the bacterial chaperonin, PapD. In the C2 crystal form which we have solved here, two MSP chains are tightly associated in the asymmetric unit and are related by a non-crystallographic 2-fold rotation axis. This arrangement almost certainly represents the MSP dimer that is present in solution. Additionally, the arrangement of two MSP dimers at one of the crystallographic 2-fold axes in the 215 A unit cell suggests a possible mode for the assembly of MSP into the filaments which promote cell movement. This dimer-dimer association is based on a beta sheet extension mechanism between adjoining MSP monomers which resembles the interaction between PapD and its protein substrate.

2.5 A resolution crystal structure of the motile major sperm protein (MSP) of Ascaris suum.,Bullock TL, Roberts TM, Stewart M J Mol Biol. 1996 Oct 25;263(2):284-96. PMID:8913307<ref>PMID:8913307</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Ascsu]]

[[Category: Bullock, T L]]

[[Category: Roberts, T M]]

[[Category: Stewart, M]]

[[Category: Sperm]]