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1nde

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Estrogen Receptor beta with Selective Triazine Modulator

Structural highlights

1nde is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ESR2_HUMAN Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

A series of 1,3,5-triazine-based estrogen receptor (ER) modulators that are modestly selective for the ERbeta subtype are reported. Compound 1, which displayed modest potency and selectivity for ERbeta vs ERalpha, was identified via high-throughput screening utilizing an ERbeta SPA-based binding assay. Subsequent analogue preparation resulted in the identification of compounds such as 21 and 43 that display 25- to 30-fold selectivity for ERbeta with potencies in the 10-30 nM range. These compounds profile as full antagonists at ERbeta and weak partial agonists at ERalpha in a cell-based reporter gene assay. In addition, the X-ray crystal structure of compound 15 complexed with the ligand binding domain of ERbeta has been solved and was utilized in the design of more conformationally restrained analogues such as 31 in an attempt to increase selectivity for the ERbeta subtype.

A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta.,Henke BR, Consler TG, Go N, Hale RL, Hohman DR, Jones SA, Lu AT, Moore LB, Moore JT, Orband-Miller LA, Robinett RG, Shearin J, Spearing PK, Stewart EL, Turnbull PS, Weaver SL, Williams SP, Wisely GB, Lambert MH J Med Chem. 2002 Dec 5;45(25):5492-505. PMID:12459017^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Henke BR, Consler TG, Go N, Hale RL, Hohman DR, Jones SA, Lu AT, Moore LB, Moore JT, Orband-Miller LA, Robinett RG, Shearin J, Spearing PK, Stewart EL, Turnbull PS, Weaver SL, Williams SP, Wisely GB, Lambert MH. A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta. J Med Chem. 2002 Dec 5;45(25):5492-505. PMID:12459017

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nde"

@@ Line 3: / Line 3: @@
 <StructureSection load='1nde' size='340' side='right'caption='[[1nde]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1nde]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NDE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1NDE FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1nde]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NDE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NDE FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MON:4-(2-{[4-{[3-(4-CHLOROPHENYL)PROPYL]SULFANYL}-6-(1-PIPERAZINYL)-1,3,5-TRIAZIN-2-YL]AMINO}ETHYL)PHENOL'>MON</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ESTRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MON:4-(2-{[4-{[3-(4-CHLOROPHENYL)PROPYL]SULFANYL}-6-(1-PIPERAZINYL)-1,3,5-TRIAZIN-2-YL]AMINO}ETHYL)PHENOL'>MON</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1nde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nde OCA], [http://pdbe.org/1nde PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nde RCSB], [http://www.ebi.ac.uk/pdbsum/1nde PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nde ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nde OCA], [https://pdbe.org/1nde PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nde RCSB], [https://www.ebi.ac.uk/pdbsum/1nde PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nde ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN]] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
+[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 36: / Line 36: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Consler, T G]]
+[[Category: Consler TG]]
-[[Category: Go, N]]
+[[Category: Go N]]
-[[Category: Hale, R L]]
+[[Category: Hale RL]]
-[[Category: Henke, B R]]
+[[Category: Henke BR]]
-[[Category: Hohman, D R]]
+[[Category: Hohman DR]]
-[[Category: Jones, S A]]
+[[Category: Jones SA]]
-[[Category: Lambert, M H]]
+[[Category: Lambert MH]]
-[[Category: Lu, A T]]
+[[Category: Lu AT]]
-[[Category: Moore, J T]]
+[[Category: Moore JT]]
-[[Category: Moore, L B]]
+[[Category: Moore LB]]
-[[Category: Orband-Miller, L A]]
+[[Category: Orband-Miller LA]]
-[[Category: Robinett, R G]]
+[[Category: Robinett RG]]
-[[Category: Shearin, J]]
+[[Category: Shearin J]]
-[[Category: Spearing, P K]]
+[[Category: Spearing PK]]
-[[Category: Stewart, E L]]
+[[Category: Stewart EL]]
-[[Category: Turnbull, P S]]
+[[Category: Turnbull PS]]
-[[Category: Weaver, S L]]
+[[Category: Weaver SL]]
-[[Category: Williams, S P]]
+[[Category: Williams SP]]
-[[Category: Wisely, G B]]
+[[Category: Wisely GB]]
-[[Category: Er]]
-[[Category: Erb]]
-[[Category: Estradiol]]
-[[Category: Estrogen]]
-[[Category: Estrogen receptor]]
-[[Category: Estrogen receptor beta]]
-[[Category: Oestrogen]]
-[[Category: Transcription]]
-[[Category: Triazine]]

1nde

From Proteopedia

Current revision

Estrogen Receptor beta with Selective Triazine Modulator

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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