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From Proteopedia
(Difference between revisions)
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So, it is really important to study this protein and understands the mechanism with which it works in order to fight the infection and discover a new anti-fungal drug that will work better for both humans and animals. | So, it is really important to study this protein and understands the mechanism with which it works in order to fight the infection and discover a new anti-fungal drug that will work better for both humans and animals. | ||
== Important amino acids == | == Important amino acids == | ||
| - | + | the catalytic cycle is initiated by the binding of NADPH resulting a reduction of the FAD. | |
The most important contributions to protein ligand interactions are H-bonds and lipophilic contacts. | The most important contributions to protein ligand interactions are H-bonds and lipophilic contacts. | ||
| - | They are driven by enthalpy and entropy. Solvation and desolvation then, affects either of the | + | They are driven by enthalpy and entropy. Solvation and desolvation then, affects either of <scene name='86/861618/Protein_view_2/12'>the ligands</scene>. On the other hand, the protein binding site plays a big role in the |
| - | binding process | + | binding process. |
== Structural highlights == | == Structural highlights == | ||
Revision as of 23:15, 6 December 2020
| This Sandbox is Reserved from 09/18/2020 through 03/20/2021 for use in CHEM 351 Biochemistry taught by Bonnie Hall at Grand View University, Des Moines, IA. This reservation includes Sandbox Reserved 1628 through Sandbox Reserved 1642. |
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References
journal article: Trapping conformational states of a flavin-dependent N-monooxygenase in crystallo reveals protein and flavin dynamics
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
