Sandbox Reserved 1628
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==Epithelial Adhesin 1A== | ==Epithelial Adhesin 1A== | ||
<StructureSection load='4af9' size='340' side='right' caption='EpaA in a complex with Galb1-3Glc' scene=''> | <StructureSection load='4af9' size='340' side='right' caption='EpaA in a complex with Galb1-3Glc' scene=''> | ||
| - | Adhesins, commonly found on the surface of bacteria, aid in binding or adhering the bacteria to other cells. This is normally the beginning of an infection as the bacteria can bind to a host cell and potentially start a cascade of events within the host cell that leads to the bacteria invading<ref>PMID:9973330</ref>. Various bacteria have various types of adhesin proteins, but this page looks specifically at epithelial adhesins, particularly one found in ''Candida glabrata'' which causes infections most often in immunosuppressed patients<ref name="yeast" | + | Adhesins, commonly found on the surface of bacteria, aid in binding or adhering the bacteria to other cells. This is normally the beginning of an infection as the bacteria can bind to a host cell and potentially start a cascade of events within the host cell that leads to the bacteria invading<ref>PMID:9973330</ref>. Various bacteria have various types of adhesin proteins, but this page looks specifically at epithelial adhesins, particularly one found in ''Candida glabrata'' which causes infections most often in immunosuppressed patients<ref name="yeast">PMID:9880475</ref> and can lead to deadly bloodstream infections. |
== Function of your Protein == | == Function of your Protein == | ||
| - | ''Candida glabrata'' is a yeast that commonly interacts with other yeast bacteria to infect humans with what are commonly known as thrush, yeast infections, and urinary tract infections<ref name="yeast" />. | + | ''Candida glabrata'' is a yeast that commonly interacts with other yeast bacteria to infect humans with what are commonly known as thrush, yeast infections, and urinary tract infections<ref name="yeast" />. Yeast grows on the human body naturally, it's only once it enters the body somehow that it starts to cause infections. For the bacteria to do this, it must first adhere to a host cell and does so by using the adhesins found on the outside of the bacteria. |
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| + | EpaA1 looks specifically for certain sugars on the outside of the host cells and will bind to those. This specific adhesin binds to beta-D-galactopyranose-(1,3)-beta-D-glucopyranose. For ''Candida glabrata'', there are about 20 different types of epithelial adhesins, each with conserved areas of the binding site and variable areas to be able to bind to a variety of sugars on the host cell<ref name="journal">PMID:32669365</ref>. | ||
//Adhesins are used for binding cells together, commonly found helping pathogens bind to host cells. This specific adhesin has a ligand of <scene name='86/861610/Ligandhighlight/1'>beta-D-galactopyranose-(1,3)-beta-D-glucopyranose.</scene> <scene name='86/861610/Bdglacbdglc/2'>A close up view of just the sugar ligand.</scene> <scene name='86/861610/Ligandandactivelabel/2'>This shows how the ligand and active site interact.</scene> | //Adhesins are used for binding cells together, commonly found helping pathogens bind to host cells. This specific adhesin has a ligand of <scene name='86/861610/Ligandhighlight/1'>beta-D-galactopyranose-(1,3)-beta-D-glucopyranose.</scene> <scene name='86/861610/Bdglacbdglc/2'>A close up view of just the sugar ligand.</scene> <scene name='86/861610/Ligandandactivelabel/2'>This shows how the ligand and active site interact.</scene> | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
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| - | <ref>PMID:32669365</ref> | ||
<references/> | <references/> | ||
Revision as of 00:57, 8 December 2020
| This Sandbox is Reserved from 09/18/2020 through 03/20/2021 for use in CHEM 351 Biochemistry taught by Bonnie Hall at Grand View University, Des Moines, IA. This reservation includes Sandbox Reserved 1628 through Sandbox Reserved 1642. |
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Epithelial Adhesin 1A
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References
- ↑ Soto GE, Hultgren SJ. Bacterial adhesins: common themes and variations in architecture and assembly. J Bacteriol. 1999 Feb;181(4):1059-71. doi: 10.1128/JB.181.4.1059-1071.1999. PMID:9973330 doi:http://dx.doi.org/10.1128/JB.181.4.1059-1071.1999
- ↑ 2.0 2.1 Fidel PL Jr, Vazquez JA, Sobel JD. Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans. Clin Microbiol Rev. 1999 Jan;12(1):80-96. PMID:9880475
- ↑ Hoffmann D, Diderrich R, Reithofer V, Friederichs S, Kock M, Essen LO, Mosch HU. Functional reprogramming of Candida glabrata epithelial adhesins: the role of conserved and variable structural motifs in ligand binding. J Biol Chem. 2020 Jul 15. pii: RA120.013968. doi: 10.1074/jbc.RA120.013968. PMID:32669365 doi:http://dx.doi.org/10.1074/jbc.RA120.013968
