1d8h

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{{Seed}}
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{{STRUCTURE_1d8h| PDB=1d8h | SCENE= }}
{{STRUCTURE_1d8h| PDB=1d8h | SCENE= }}
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'''X-RAY CRYSTAL STRUCTURE OF YEAST RNA TRIPHOSPHATASE IN COMPLEX WITH SULFATE AND MANGANESE IONS.'''
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===X-RAY CRYSTAL STRUCTURE OF YEAST RNA TRIPHOSPHATASE IN COMPLEX WITH SULFATE AND MANGANESE IONS.===
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==Overview==
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RNA triphosphatase is an essential mRNA processing enzyme that catalyzes the first step in cap formation. The 2.05 A crystal structure of yeast RNA triphosphatase Cet1p reveals a novel active site fold whereby an eight-stranded beta barrel forms a topologically closed triphosphate tunnel. Interactions of a sulfate in the center of the tunnel with a divalent cation and basic amino acids projecting into the tunnel suggest a catalytic mechanism that is supported by mutational data. Discrete surface domains mediate Cet1p homodimerization and Cet1p binding to the guanylyltransferase component of the capping apparatus. The structure and mechanism of fungal RNA triphosphatases are completely different from those of mammalian mRNA capping enzymes. Hence, RNA triphosphatase presents an ideal target for structure-based antifungal drug discovery.
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(as it appears on PubMed at http://www.pubmed.gov), where 10589681 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10589681}}
==About this Structure==
==About this Structure==
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[[Category: Polynucleotide 5'-triphosphatase]]
[[Category: Polynucleotide 5'-triphosphatase]]
[[Category: Rna triphosphatase]]
[[Category: Rna triphosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:34:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:40:17 2008''

Revision as of 19:40, 30 June 2008

Image:1d8h.png

Template:STRUCTURE 1d8h

X-RAY CRYSTAL STRUCTURE OF YEAST RNA TRIPHOSPHATASE IN COMPLEX WITH SULFATE AND MANGANESE IONS.

Template:ABSTRACT PUBMED 10589681

About this Structure

1D8H is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of yeast RNA triphosphatase: an essential component of the mRNA capping apparatus., Lima CD, Wang LK, Shuman S, Cell. 1999 Nov 24;99(5):533-43. PMID:10589681

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