This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1d8z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1d8z.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1d8z.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1d8z| PDB=1d8z | SCENE= }}
{{STRUCTURE_1d8z| PDB=1d8z | SCENE= }}
-
'''SOLUTION STRUCTURE OF THE FIRST RNA-BINDING DOMAIN (RBD1) OF HU ANTIGEN C (HUC)'''
+
===SOLUTION STRUCTURE OF THE FIRST RNA-BINDING DOMAIN (RBD1) OF HU ANTIGEN C (HUC)===
-
==Overview==
+
<!--
-
Hu antigen C (HuC) has three RNA-binding domains (RBDs). The N-terminal two, RBD1 and RBD2, are linked in tandem and bind to the AU-rich elements (AREs) in the 3'-untranslated region of particular mRNAs. The solution structures of HuC RBD1 and RBD2 were determined by NMR methods. The HuC RBD1 and RBD2 structures are quite similar to those of Sxl RBD1 and RBD2, respectively. The individual RBDs of HuC, RBD1 and RBD2 in isolation can interact rather weakly with the minimal ARE motif, AUUUA, while the didomain fragment, RBD1-RBD2, of HuC binds more tightly to a longer ARE RNA, UAUUUAUUUU. Chemical shift perturbations by the longer RNA on HuC RBD1-RBD2 were mapped on and around the two beta-sheets and on the C-terminal region of RBD1. The HuC RBD1-RBD2 residues that exhibited significant chemical shift perturbations coincide with those conserved in Sxl RBD1-RBD2. These data indicate that the RNA-binding characteristics of the HuC and Sxl didomain fragments are similar, even though the target RNAs and the biological functions of the proteins are different.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10734193}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10734193 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10734193}}
==About this Structure==
==About this Structure==
-
1D8Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D8Z OCA].
+
1D8Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D8Z OCA].
==Reference==
==Reference==
Line 31: Line 35:
[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:35:02 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:41:20 2008''

Revision as of 19:41, 30 June 2008

Image:1d8z.png

Template:STRUCTURE 1d8z

SOLUTION STRUCTURE OF THE FIRST RNA-BINDING DOMAIN (RBD1) OF HU ANTIGEN C (HUC)

Template:ABSTRACT PUBMED 10734193

About this Structure

1D8Z is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

NMR studies on functional structures of the AU-rich element-binding domains of Hu antigen C., Inoue M, Muto Y, Sakamoto H, Yokoyama S, Nucleic Acids Res. 2000 Apr 15;28(8):1743-50. PMID:10734193

Page seeded by OCA on Mon Jun 30 22:41:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1d8z"
Personal tools