1d9k

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{{STRUCTURE_1d9k| PDB=1d9k | SCENE= }}
{{STRUCTURE_1d9k| PDB=1d9k | SCENE= }}
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'''CRYSTAL STRUCTURE OF COMPLEX BETWEEN D10 TCR AND PMHC I-AK/CA'''
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===CRYSTAL STRUCTURE OF COMPLEX BETWEEN D10 TCR AND PMHC I-AK/CA===
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==Overview==
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The crystal structure of a complex involving the D10 T cell receptor (TCR), 16-residue foreign peptide antigen, and the I-Ak self major histocompatibility complex (MHC) class II molecule is reported at 3.2 angstrom resolution. The D10 TCR is oriented in an orthogonal mode relative to its peptide-MHC (pMHC) ligand, necessitated by the amino-terminal extension of peptide residues projecting from the MHC class II antigen-binding groove as part of a mini beta sheet. Consequently, the disposition of D10 complementarity-determining region loops is altered relative to that of most pMHCI-specific TCRs; the latter TCRs assume a diagonal orientation, although with substantial variability. Peptide recognition, which involves P-1 to P8 residues, is dominated by the Valpha domain, which also binds to the class II MHC beta1 helix. That docking is limited to one segment of MHC-bound peptide offers an explanation for epitope recognition and altered peptide ligand effects, suggests a structural basis for alloreactivity, and illustrates how bacterial superantigens can span the TCR-pMHCII surface.
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(as it appears on PubMed at http://www.pubmed.gov), where 10583947 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10583947}}
==About this Structure==
==About this Structure==
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[[Category: Mhc class ii]]
[[Category: Mhc class ii]]
[[Category: T-cell receptor]]
[[Category: T-cell receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:36:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:42:46 2008''

Revision as of 19:42, 30 June 2008

Image:1d9k.png

Template:STRUCTURE 1d9k

CRYSTAL STRUCTURE OF COMPLEX BETWEEN D10 TCR AND PMHC I-AK/CA

Template:ABSTRACT PUBMED 10583947

About this Structure

1D9K is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

The crystal structure of a T cell receptor in complex with peptide and MHC class II., Reinherz EL, Tan K, Tang L, Kern P, Liu J, Xiong Y, Hussey RE, Smolyar A, Hare B, Zhang R, Joachimiak A, Chang HC, Wagner G, Wang J, Science. 1999 Dec 3;286(5446):1913-21. PMID:10583947

Page seeded by OCA on Mon Jun 30 22:42:46 2008

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