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1pxe

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Revision as of 06:25, 2 March 2022

Solution Structure of a CCHHC Domain of Neural Zinc Finger Factor-1

Structural highlights

1pxe is a 1 chain structure with sequence from Buffalo rat. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:	NZF-1 (Buffalo rat)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[MYT1L_RAT] May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendrogalia in the CNS.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The structure of a CCHHC zinc-binding domain from neural zinc finger factor-1 (NZF-1) has been determined in solution though the use of NMR methods. This domain is a member of a family of domains that have the Cys-X(4)-Cys-X(4)-His-X(7)-His-X(5)-Cys consensus sequence. The structure determination reveals a novel fold based around a zinc(II) ion coordinated to three Cys residues and the second of the two conserved His residues. The other His residue is stacked between the metal-coordinated His residue and a relatively conserved aromatic residue. Analysis of His to Gln sequence variants reveals that both His residues are required for the formation of a well-defined structure, but neither is required for high-affinity metal binding at a tetrahedral site. The structure suggests that a two-domain protein fragment and a double-stranded DNA binding site may interact with a common two-fold axis relating the two domains and the two half-sites of the DNA-inverted repeat.

Solution structure of a CCHHC domain of neural zinc finger factor-1 and its implications for DNA binding.,Berkovits-Cymet HJ, Amann BT, Berg JM Biochemistry. 2004 Feb 3;43(4):898-903. PMID:14744132^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Kim JG, Armstrong RC, v Agoston D, Robinsky A, Wiese C, Nagle J, Hudson LD. Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. J Neurosci Res. 1997 Oct 15;50(2):272-90. PMID:9373037
↑ Berkovits-Cymet HJ, Amann BT, Berg JM. Solution structure of a CCHHC domain of neural zinc finger factor-1 and its implications for DNA binding. Biochemistry. 2004 Feb 3;43(4):898-903. PMID:14744132 doi:10.1021/bi035159d

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pxe"

@@ Line 3: / Line 3: @@
 <StructureSection load='1pxe' size='340' side='right'caption='[[1pxe]], [[NMR_Ensembles_of_Models | 21 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1pxe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1PXE FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1pxe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PXE FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NZF-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NZF-1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1pxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pxe OCA], [http://pdbe.org/1pxe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pxe RCSB], [http://www.ebi.ac.uk/pdbsum/1pxe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pxe ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pxe OCA], [https://pdbe.org/1pxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pxe RCSB], [https://www.ebi.ac.uk/pdbsum/1pxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pxe ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/MYT1L_RAT MYT1L_RAT]] May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendrogalia in the CNS.<ref>PMID:9373037</ref>
+[[https://www.uniprot.org/uniprot/MYT1L_RAT MYT1L_RAT]] May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendrogalia in the CNS.<ref>PMID:9373037</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

1pxe

From Proteopedia

Revision as of 06:25, 2 March 2022

Solution Structure of a CCHHC Domain of Neural Zinc Finger Factor-1

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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